RT Journal Article ID 4dad764c4a6e0815 A1 Vitak, Taras Y. A1 Wasser, Solomon P. A1 Nevo, Eviatar D. A1 Sybirna, Nataliya O. T1 Enzymatic System of Antioxidant Protection of Erythrocytes in Diabetic Rats Treated with Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Agaricomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2017 FD 2017-10-16 VO 19 IS 8 SP 697 OP 708 K1 Agaricus brasiliensis K1 erythrocytes K1 Ganoderma lucidum K1 medicinal mushrooms K1 oxidative stress K1 streptozotocin AB Excessive glucose concentrations in blood and cells promote the intensification of auto-oxidation. This is one of the mechanisms through which free radicals form in hyperglycemia. As a result of hyperglycemia, oxidative stress develops and lipid peroxidation (LPO) is enhanced. Erythrocytes are particularly susceptible to reactive oxygen species and LPO, which can violate cell functions. This article describes the analysis of the influence of mycelia from the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum on the enzymatic link of the antioxidant system in rat erythrocytes under streptozotocin-induced diabetes mellitus. Oxidative stress was strengthened in red blood cells of diabetic rats, as evidenced by decreased activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, and by increased amounts of thiobarbituric acid–positive products, which are markers of LPO. Administration of A. brasiliensis and G. lucidum submerged cultivated mycelial powder to animals with streptozotocin-induced diabetes restored superoxide dismutase, catalase, and glutathione peroxidase activity and reduced the amounts of thiobarbituric acid–positive products to control values, but did not affect the activity of glutathione reductase. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,32c8651274405055,4dad764c4a6e0815.html