RT Journal Article
ID 500f02e8350b63db
A1 Melnyk, Andrii V. 
A1 Zaichko, Nataliia V. 
A1 Khodakovskyi, Oleksii A. 
A1 Khodakivska, Olga V. 
T1 Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium
JF International Journal of Physiology and Pathophysiology
JO IJPP
YR 2018
FD 2018-11-20
VO 9
IS 4
SP 325
OP 333
K1 hydrogen sulfide
K1 cardiac hemodynamics
K1 ischemia-reperfusion
K1 sex
AB The changes in cardiac hemodynamics against the background of ischemia-reperfusion in 40 male and female white rats and their relationship with the level of hydrogen sulfide (H<sub>2</sub>S) in the blood serum were studied. In a model of ischemia-reperfusion injury, we evaluated the parameters of cardiac hemodynamics (microcirculation rate, left ventricle oxygen saturation, right and left ventricular pressure) and hydrogen sulfide content in the blood serum. It has been found that in males background levels of microcirculation coefficient in the left ventricle and the content of H<sub>2</sub>S in the blood serum are significantly lower (by 9-18&#37;) than those in females. Under experimental occlusion of the left coronary artery, H<sub>2</sub>S level decreases in the blood serum (in males by 64.5&#37;, in females by 51.1&#37;), which is accompanied by an inhibition of microcirculation and oxygen supply of the left ventricle cardiomyocytes (microcirculation coefficient and oxygen saturation are reduced), by weakening the contractive capacity and violation of intraventricular hemodynamics (pressure is reduced in left and right ventricles). These changes are more pronounced in males compared to females. Reperfusion of coronary vessels in animals of both sexes does not cause total recovery of H<sub>2</sub>S content in the serum and cardiac hemodynamics indicators to the background levels, indicating the formation of no-reflow coronary circulation syndrome. Infusion of NaHS not only prevents ischemia of the heart muscle, but also contributes to a more complete recanalization by improving effective perfusion in both males and females. Correlative analysis has shown that H<sub>2</sub>S level in the blood serum reveals direct links with microcirculation coefficient, left ventricle oxygen saturation, right and left ventricular pressure (in males, <i>r</i> &#61; 0.54-0.62; in females, <i>r</i> &#61; 0.60-0.70). These data suggest an important role of H<sub>2</sub>S system in the regulation of microcirculation and cardiac hemodynamics in male and female rats against the background of ischemia-reperfusion.



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