RT Journal Article
ID 510ed6050a9499eb
A1 Tkachenko, Yanina V. 
A1 Vorobiova, Ganna M. 
A1 Zhovnir, Volodumyr A. 
A1 Yemets, Illya N. 
T1 Impact of Autologous Umbilical Cord Blood and Donor Blood Transfusion on Cytokine Profile in Neonates with Transposition of the Great Arteries
JF International Journal of Physiology and Pathophysiology
JO IJPP
YR 2013
FD 2013-08-30
VO 4
IS 2
SP 83
OP 90
K1 autologous umbilical cord blood
K1 Transposition Of The Great Arteries
K1 Tumor Necrosis Factor &#945;
K1 Interleukin 1&#946; (IL-1&#946;)
K1 IL-6
K1 IL-8
K1 IL-10
AB We studied the level of pro- and anti-inflammatory cytokines such as tumor necrosis factor &#945; (TNF &#945;), interleukin 1&#946; (IL-1&#946;), IL-6, IL-8 and IL-10 in the blood serum of neonates with transposition of great arteries (TGA) who underwent arterial switch operation (ASO) in the first hours of life using autologous umbilical cord blood transfusion (AUCBT group). These patients were compared with neonates underwent ASO in the first days of life using donor blood transfusion during operative period (DBT group) It has been found that the serum IL-6, IL-8, IL-1&#946; and TNF&#945; concentrations was increased significantly pre- and postoperatively in neonates from DBT group, while the serum IL-10 concentrations was decreased. In neonates from AUCBT group preoperative concentrations of cytokines did not differ significantly from healthy neonates and was significantly lower than in DBT group. Postoperative concentrations of IL-6, IL-8, IL-1&#946; and TNF &#945; cytokines increased on the 1<sup>st</sup> day after operation and then gradually decreased till the 7<sup>th</sup> day after surgery, while in neonates from DBT group it remains significant during all postoperative period. Neonates from AUCBT group demonstrated adequate immune response to the ongoing operation. Accelerated interleukin expression and an abnormal cytokine balance in DBT group were associated with postoperative pulmonary complications and hyperthermia.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,3301bbf015c9d744,510ed6050a9499eb.html