RT Journal Article
ID 51daee9d54a47303
A1 Xie, Longxiang
A1 Zeng, Jie
A1 Luo, Hongping
A1 Pan, Weihua
A1 Xie, Jianping
T1 The Roles of Bacterial GCN5-Related N-acetyltransferases
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2014
FD 2014-02-19
VO 24
IS 1
SP 77
OP 87
K1 GCN5-related N-acetyltransferases
K1 acetylation
K1 M. tuberculosis
AB The GCN5-related N-acetyltransferase (GNAT) superfamily of proteins, widespread in eukaryotes and prokaryotes, can utilize acyl coenzyme A (acyl CoA) to acylate respective acceptor substrates and release both CoA and the acylated products. GNATs have been shown to be involved in multiple physiological events, including bacterial drug resistance, regulation of transcription, stress reaction, and metabolic flux, etc. In the last few years, the importance of GNATs has only emerged in eukaryotes, but bacterial GNATs, particularly those of pathogens, have only recently been explored. In this review, we summarize the main members, structures, inhibitors, and activators of proteins in the GNAT family. We focus on the roles of GNATs in bacteria, particularly Mycobacterium tuberculosis GNATs.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,75feda1245856cd3,51daee9d54a47303.html