RT Journal Article
ID 561e1e517a32f28b
A1 Zhang, Wei
A1 Hong, Jau-Shyong
A1 Kim, Hyoung-Chun
A1 Zhang, Wanqin
A1 Block, Michelle L.
T1 Morphinan Neuroprotection: New Insight into the Therapy of Neurodegeneration
JF Critical Reviews™ in Neurobiology
JO CRN
YR 2004
FD 2005-03-28
VO 16
IS 4
SP 271
OP 302
AB Neuro-inflammation plays a pivotal role in numerous neurodegenerative disorders, such as Parkinson’s disease (PD). Traditional anti-inflammatory drugs have limited therapeutic use because of their narrow spectrum and severe side effects after long-term use. Morphinans are a class of compounds containing the basic morphine structure. The following review will describe novel neuroprotective effects of several morphinans in multiple inflammatory disease models. The potential therapeutic utility and underlying mechanisms of morphinan neuroprotection are discussed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/7b004699754c9fe6,5f636f6a33184c63,561e1e517a32f28b.html