RT Journal Article ID 5cb61c2401bcaa57 A1 Sakata, Shigeki T1 Autoimmunity against Thyroid Hormones JF Critical Reviews™ in Immunology JO CRI YR 1994 FD 1994-06-30 VO 14 IS 2 SP 157 OP 191 K1 thyroid hormone autoantibodies K1 triiodothyronine K1 thyroxine K1 thyroglobulin K1 hormonogenic site K1 radioimmunoassay K1 Graves' disease K1 Hashimoto's thyroiditis. AB The presence of thyroid hormone autoantibodies (THAA) is a common phenomenon. More than 270 cases have been reported by the end of 1993 involving not only thyroidal but also nonthyroidal disorders. Clinically, THAA in a patient's serum produces variation in thyroid hormone metabolism and, in particular, may interfere with the radioimmunoassay (RIA) results of total or free thyroid hormone measurements, which can cause unusually high or low values of the hormones depending on the B/F separation method used. This in vitro interference can give clinicians confusing information about the patient’s thyroid state. As a result, the patient may receive inappropriate treatment from physicians who are unaware of this disorder. The presence of THAA has been reported not only in humans but also in dogs, chickens, and rats. In this review article, clinical features of THAA and the mechanism of autoantibody production are discussed. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,3dde19f3158ddb3b,5cb61c2401bcaa57.html