RT Journal Article
ID 6605612b26921f04
A1 Pishel, Iryna M.
A1 Yevtushenko, Olga O.
A1 Leonov, Yuriy I.
A1 Grygorieva, Nataliia V.
A1 Orlyk, Tatiana V.
A1 Shytikov, Dmytro V.
A1 Povoroznyuk, Vladyslav V.
A1 Butenko, Gennadi M.
T1 The Association of A−1082→G Polymorphism of IL-10 and (A−308→G) Polymorphism of TNFα Genes with Bone Density in Elderly Women
JF International Journal of Physiology and Pathophysiology
JO IJPP
YR 2010
FD 2010-12-22
VO 1
IS 4
SP 315
OP 327
K1 gene polymorphisms
K1 bone
K1 aging
K1 IL-10
K1 TNFalpha
AB We studied the association between bone mineral density and (A −1082→G) polymorphism of IL-10 and (A−308→G) polymorphism of TNFα genes. SNP-polymerase chain reaction was used. The study failed to find significant association of A−308→G TNFα polymorphism and bone state in postmenopausal women. The patients with AA genotype of A−1082→G IL-10 gene have significantly lower indices of bone mineral density comparing with G allele carriers (GG/AG). This association remained true for data of bone mineral density of total body, and separate parts of skeleton: lumbar spine, femoral neck, Ward's triangle of total femur. Our study indicates that A−308→G polymorphism of TNFα gene is not associated with indices of bone mineral density in postmenopausal women. However, there is strong evidence that women, carriers of AA genotype of A−1082→G polymorphism of IL-10 gene have significantly lower indices of bone mineral density. This indicates the potential for predictive genetic testing of osteoporosis risk. Analyses of gene combination IL-10 G−1082→G and TNFα G−308→G ('antiinflammatory genotype') did not show any significant association of this genotype with bone characteristics, which shows low predictive value of this combination for diagnostics of osteoporosis.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,2397ed4120ab976b,6605612b26921f04.html