RT Journal Article
ID 6d04c1201a21acb4
A1 Kujundzic, Renata Novak
A1 Zarkovic , Neven
A1 Troselj, Koraljka Gall
T1 Pyridine Nucleotides in Regulation of Cell Death and Survival by Redox and Non-Redox Reactions
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2014
FD 2014-10-23
VO 24
IS 4
SP 287
OP 309
K1 pyridine nucleotide
K1 oxidative stress
K1 energy metabolism
K1 poly(ADP-ribose) polymerase
K1 sirtuin
K1 sphingolipid
AB Changes of the level and ratios of pyridine nucleotides determine metabolism- dependent cellular redox status and the activity of poly(ADP-ribose) polymerases (PARPs) and sirtuins, thereby influencing several processes closely related to cell survival and death. Pyridine nucleotides participate in numerous metabolic reactions whereby their net cellular level remains constant, but the ratios of NAD+/NADP+ and NADH/NADPH oscillate according to metabolic changes in response to diverse stress signals. In non-redox reactions, NAD+ is degraded and quickly, afterward, resynthesized in the NAD+ salvage pathway, unless overwhelming activation of PARP-1 consumes NAD+ to the point of no return, when the cell can no longer generate enough ATP to accommodate NAD+ resynthesis. The activity of PARP-1 is mandatory for the onset of cytoprotective autophagy on sublethal stress signals. It has become increasingly clear that redox status, largely influenced by the metabolism-dependent composition of the pyridine nucleotides pool, plays an important role in the synthesis of pro-apoptotic and anti-apoptotic sphingolipids. Awareness of the involvement of the prosurvival sphingolipid, sphingosine-1-phosphate, in transition from inflammation to malignant transformation has recently emerged. Here, the participation of pyridine nucleotides in redox and non-redox reactions, sphingolipid metabolism, and their role in cell fate decisions is reviewed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,76b3452a55cd7eeb,6d04c1201a21acb4.html