RT Journal Article
ID 6dbb531635063bb2
A1 Belotserkovskaya , Rimma 
A1 Berger, Shelley L. 
T1 Interplay between Chromatin Modifying and Remodeling Complexes in Transcriptional Regulation
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 1999
FD 1999-12-20
VO 9
IS 3-4
SP 221
OP 230
K1 SWI/SNF
K1 SAGA
K1 chromatin remodeling
K1 histone modification.
AB The question of a possible functional relationship between different chromatin-altering enzymatic activities is of great interest. Several remarkable parallels have been revealed regarding the action of the remodeling complex SWI/SNF and the histone acetylation complex SAGA during transcriptional activation in<i> S. cerevisiae</i>. Many promoters, but not all, that require one complex require the other as well. Mutations that disrupt both complexes cause much more severe phenotypes than single mutations. Both types of complexes are recruited to specific promoters by interaction with DNA-bound acidic activators, resulting in targeted acetylation and transcriptional activation. Taken together the data argue for independent mechanisms, but similar recruitment and functional interplay between these two types of chromatin-altering activities.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,7831059776a36f5d,6dbb531635063bb2.html