RT Journal Article ID 7364ecf355261371 A1 Crane, Isabel J. A1 Forrester, John V. T1 Th1 and Th2 Lymphocytes in Autoimmune Disease JF Critical Reviews™ in Immunology JO CRI YR 2005 FD 2005-06-07 VO 25 IS 2 SP 75 OP 102 AB This review reconsiders how the Th1/Th2 paradigm can be applied to Th1-mediated autoimmune disease. Although there is evidence that autoimmune diseases such as multiple sclerosis, type 1 insulin-dependent diabetes mellitus, and posterior uveitis are Th1 mediated and that in some cases reduction of the Th1 response or a Th2 type shift may alleviate disease, many apparent exceptions are now well documented. These exceptions center around the contradictory actions of the Th1 cytokine IFN-γ and the evidence that Th2 lymphocytes can also cause disease. Recent information on the regulation of Th1 and Th2 lymphocytes in terms of the innate immune response and by other T cells helps to clarify the reasons for some of these discrepancies and enables the Th1/Th2 concept to be accepted as an integral part of the complex interactions occurring as autoimmune disease develops. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,4491c3b513904962,7364ecf355261371.html