ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.625 5年インパクトファクター: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2015012017
pages 105-113

Antitumor Potential of Thevetia peruviana on Ehrlich's Ascites Carcinoma−Bearing Mice

Sagnik Haldar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Indrajit Karmakar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
Mainak Chakraborty
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
Dilshad Ahmad
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India; TCS Research, TRDDC, Pune, Maharashtra, India
Pallab Kanti Haldar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India

要約

Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12 ml, 2.88±0.23 ml, and 1.34±0.17 ml for the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. Nonviable cell counts were 4.44%±0.42%, 18.57%±3.07%, and 68.12%±5.32% in the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. METP-treated EAC cell-bearing mice had an increased life span (48.69% and 83.78%) compared to the EAC control group. Hematological and serum biochemical profiles were restored to normal levels in METP-treated mice compared to the EAC control group. METP significantly (P<0.001) decreased lipid peroxidation and recovered reduced glutathione, superoxide dismutase, and catalase toward normal levels compared to the EAC control group. In summary, METP exhibited remarkable antitumor activity in Swiss albino mice, which is plausibly attributable to its augmentation of endogenous antioxidant mechanisms.


Articles with similar content:

Chemopreventive Property of Trichosanthes dioica Root Against 3-Methylcholanthrene-induced Carcinogenesis in Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Sanjib Bhattacharya, Pallab Kanti Haldar
Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 2
Qing Wang, Meifang Huang, Yuanyuan Zheng, Kai Zheng, Liqiong Zhang
Chemopreventive Efficacy of (+)-Catechin-Rich Aqueous Extract of Acacia catechu Willd. Heartwood against 7,12-Dimethylbenz[a]Anthracene-Induced Hepatocarcinoma in Balb/c Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Manu Sharma, Jitender Monga, Chetan Singh Chauhan
Effect of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Mycelium on Benzo[a]prene-Induced Early Alterations of the Respiratory Epithelium in the Hypercholesterolaemic Rats
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Suhaila Mohamed, Chow Chin Tong, Nor Aini B. Umar, Mohamed Mustapha Noordin, Yew Keong Choong
Effects of 10-GHz Microwaves on Hematological Parameters in Swiss Albino Mice and Their Modulation by Prunus avium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
K. V. Sharma, Rashmi Sisodia, Preeti Srivastava, Faiza Rifat, Archana Sharma