ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.625 5年インパクトファクター: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i3.70
pages 245-253

Maternal Intake of N-nitroso Compounds from Cured Meat and the Risk of Pediatric Brain Tumors: A Review

Michael Huncharek
Division of Radiation Oncology, John Cochrane VA Medical Center, St. Louis, Department of Clinical Oncology, Marsh. eld Clinic Cancer Center, Marshfield, Wisconsin and Meta-Analysis Research Group, Stevens Point, Wisconsin

要約

Experimental investigations conducted over the last several decades suggest that transplacental exposure of offspring to certain N-nitroso compounds (NOCs) results in the development of brain tumors in laboratory animals. Dietary cured meats are a recognized source of such exposures in humans, which raises the possibility that maternal consumption of cured meat products during pregnancy could increase the risk of childhood brain tumors. This hypothesis was first suggested by an observational study conducted by Preston-Martin et al. in 1982 supporting such a role in human disease. Since that time, additional epidemiological analyses have been performed addressing this hypothesis although results are inconsistent across studies. Due to the possible impact of bias and confounding in the available observational studies, the relatively weak effect seen in some observational analyses is of questionable validity. Nonetheless, since the association of transplacental NOC exposure and brain tumor risk is biologically plausible, the suspected association cannot be unequivocally dismissed. This paper reviews the current epidemiological evidence dealing with the maternal cured meat intake/childhood brain tumor association and suggests further avenues for research.


Articles with similar content:

Association of ERCC1 Polymorphisms with the Risk of Colorectal Cancer: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Jiansong Jiang, Jianfeng Chen, Ningjie Sun, Gaojian Luo, Xiansheng Chen, Gang Hu, Haiming Wu
Dietary Cured Meat and the Risk of Adult Glioma: A Meta-Analysis of Nine Observational Studies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.22, 2003, issue 2
Lamar Wheeler, Michael Huncharek, Bruce Kupelnick
ADAMTS7 and ZC3HC1 Share Genetic Predisposition to Coronary Artery Disease and Large Artery Ischemic Stroke
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 4
Malihe Dadgarmoghaddam, Simin Jafaripour, Ariane Sadr-Nabavi, Payam Sasanejad
The Multilayered Regulation of the Oncogenic Protein YY1
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Raed Rizkallah, Myra M. Hurt
Pediatric Rhabdomyosarcoma
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 3-4
Jack F. Shern, Marielle E. Yohe, Javed Khan