ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.241 5年インパクトファクター: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.110
11 pages

Low Doses of Heavy Metals Disrupt Normal Structure and Function of Rat Platelets

Siragam Vinaya Kumar
Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University,West Bengal, India
Rakhi Bose
Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University,West Bengal, India
Shelley Bhattacharya
Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University,West Bengal, India

要約

Aggregation, an important property of platelets, plays a key role in the coagulation of blood and is potentiated by ADP and adrenaline, whereas cAMP acts as a strong inhibitor. Because of the rise in the heavy metal load in the environment, more studies are necessary to look at its subtle effects in the animal system, wherein platelet structure and function can be targeted. We carried out structural analyses under phase contrast and scanning electronmicroscopy of the platelets prepared from 1/10 LD50 metal-treated rats. After mercury (Hg) and arsenic (As) treatment, the cell margins appeared irregular and wavy, with small pseudopodia-like protrusions from the surface. Cadmium (Cd) treatment caused loss of the general spindle shape, and the platelets assumed a round spongy appearance. All metal treatments effected enhanced collagen-induced aggregation and inhibited ADP and arachidonic acid-induced aggregation, whereas epinephrine accelerated aggregation in Hg and Cd treatment but inhibited aggregation in As treatment. Cd proved a potent inhibitor of phosphodiesterase, increasing the cAMP level in in vitro treatments at equimolar (5, 10, and 20 pmoles) concentrations. The rate of aggregation was enhanced with all the agonists used in in vitro Hg and As treatments, with concomitant reduction in cAMP, while Cd inhibited platelet aggregation. Thus, we can conclude that cytosolic cAMP, which is decreased by the metal-induced inhibition of phosphodiesterase, is a regulator molecule in platelet aggregation. Furthermore, it is also abundantly clear that equimolar doses of metals are not always equitoxic. Therefore, the action of each xenobiotic is not only due to the concentration used but also to the type of xenobiotic depending on its unique mechanism of action.


Articles with similar content:

Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride−Induced Dementia in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 2
Grandhi Venkata Ramalingayya, Madhavan Nampoothiri, Nampurath Gopalan Kutty, Chamallamudi Mallikarjuna Rao, Nandakumar Krishnadas
Accelerated Proteasomal Activity Induced by Pb2+, Ga3+, or Cu2+ Exposure Does Not Induce Degradation of αt-Synuclein
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 1
Nurit Grunberg-Etkovitz, Almog Avital, Daniel Offen, Zvi Malik, Nirit Lev, Debby Ickowicz
The Experimental Investigation of Modified Surface Effect on Microbial Fouling Characteristics
International Heat Transfer Conference 15, Vol.35, 2014, issue
Zhong-Bin Zhang, LIU Zuodong, Yilong ZHANG, L. Wu, Zhi-ming Xu
Oxidative Stress and Antioxidant Defenses in Asthmatic Murine Model Exposed to Printer Emissions and Environmental Tobacco Smoke
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 4
So Min Lee, Durga Bhavani Konga, Cheol Min Lee, Seung Cheol Hong, Ki Youn Kim, Young Man Roh, Yoonshin Kim
Resveratrol Alleviates Cadmium-Induced Damage and Overexpression of Epidermal Growth Factor Receptor and its Downstream Signaling Proteins in the Reproductive System of Male Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 1
Syamsundar Mandal, Sudipta Ray, Paramita Ghosh, Murmu Nabendu, Samir Banerjee, Rinku Saha, Sanchita Rauth, Sayantan Bhattacharyya, Sreyashi Mitra