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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

The Influence of Nonprotein Thiols on DNA Damage Induced by Bleomycin in Single Human Cells

巻 32, 発行 3, 2013, pp. 219-228
DOI: 10.1615/JEnvironPatholToxicolOncol.2013004670
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要約

Nonprotein thiols are considered radioprotectors, preventing DNA damage by ionizing radiation. Because bleomycin (BLM) is a radiomimetic agent, it was proposed that thiols may prevent DNA damage produced by this antibiotic. However, results obtained with treatments combining thiols and BLM in living cells are contradictory. The goal of this study was to analyze the DNA damage induced by BLM and the influence of 3 nonprotein thiols of different electrical charges and chemical compositions at the level of single cells (comet assay). We also studied the morphological signs of apoptosis produced by BLM in these same conditions. We found that all thiols potentiated DNA damage induced by BLM, most probably by reactivating the BLM complex once it generated free radicals. Cysteamine (positive) potentiated BLM action the most, glutathione (negative) potentiated this antibiotic the least, whereas cysteine had an intermediate effect compared with the other two.

によって引用された
  1. Laffon Blanca, Fernández-Bertólez Natalia, Costa Carla, Pásaro Eduardo, Valdiglesias Vanessa, Comparative study of human neuronal and glial cell sensitivity for in vitro neurogenotoxicity testing, Food and Chemical Toxicology, 102, 2017. Crossref

  2. Olsen Cathrine Elisabeth, Sellevold Simen, Theodossiou Theodossis, Patzke Sebastian, Berg Kristian, Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin, Photodiagnosis and Photodynamic Therapy, 20, 2017. Crossref

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