ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.625 5年インパクトファクター: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2019030154
pages 229-238

Assessment of the Therapeutic Effects of Fucoxanthin by Attenuating Inflammation in Ovalbumin-Induced Asthma in an Experimental Animal Model

Xinjun Yang
Department of Pediatrics, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong City, Shaanxi Province, China
Gang Guo
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Minyan Dang
Department of Scientific Research, Innoscience Research SDN BHD, Subang Jaya, 47650, Selangor, Malaysia
Lei Yan
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Xin Kang
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Kunjin Jia
Innoscience Research Sdn. Bhd, Subang Jaya, Selangor, Malaysia
Hong Ren
Department of Pediatrics, Ninth Hospital of Xi'an, Xi'an, Shaanxi Province, China

要約

Asthma has affected more than 300 million people worldwide and is considered one of the most debilitating global public health problems based on a recent statistical report from the Global Initiative for Asthma. Inflammation of the airways leads to the various interrelated mechanisms of innate and adaptive immunity acting mutually with the epithelium of the respiratory organ. Fucoxanthin is an orange or brown pigment which is naturally found in various seaweeds. To the best of our knowledge, there are no scientific claims or evidence of the curative effects of fucoxanthin against asthma. Hence, this present research was designed to investigate the curative activity of fucoxanthin against ovalbumin-induced asthma in a mouse model. Fucoxanthin (50 mg/kg) showed significant (P < 0.001) antiasthma activity. It effectively decreased intracellular secretion of reactive oxygen species and increased antioxidant enzyme activity. Fucoxanthin also decreased inflammatory cytokine markers in bronchoalveolar lavage fluid. Because fucoxanthin showed effective antiasthma activity against ovalbumin-induced asthma in experimental animals, further research on this natural antioxidant could lead to development of a novel drug for the treatment of asthma in humans.

参考

  1. GINA. Global initiative for asthma, global strategy for asthma management and prevention. 2016. Accessed 7 Feb 2017. Available from: http://ginasthma.org/ 2016-gina-reportglobalstrategy-for-asthma-management-and-pre-vention.

  2. Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, De Jongste JC, Lemanske RF. A summary of the new GINA strategy: a roadmap to asthma control. Eur Resp J. 2015 Sep 1;46(3):622-39.

  3. Costa E, Bregman M, Araujo DV, Costa CH, Rufino R. Asthma and the socio-economic reality in Brazil. World Allergy Organ J. 2013 Dec;6(1):1.

  4. Nunes C, Pereira AM, Morais-Almeida M. Asthma costs and social impact. Asthma Res Pract. 2017 Dec;3(1):1.

  5. Tiotiu A. Biomarkers in asthma: state of the art. Asthma Res Pract. 2018; 4(1):10.

  6. Rosa SI, Rios-Santos F, Balogun SO, de Almeida DA, Damazo AS, da Cruz TC, Pavan E, dos Santos Barbosa R, da Costa Alvim T, Soares IM, Ascencio SD. Hydroethanolic extract from Echinodorus scaber Rataj leaves inhibits inflammation in ovalbumin-induced allergic asthma. J Ethnopharmacol. 2017 May 5;203:191-9.

  7. Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC. Oxidative stress and cardiovascular risk: obesity, diabetes, smoking, and pollution. J Am College Cardiol. 2017 Jul 3;70(2):230-51.

  8. Hall S, Agrawal DK. Key mediators in the immunopath- ogenesis of allergic asthma. Int Immunopharmacol. 2014 Nov 1;23(1):316-29.

  9. Johnathan M, Gan SH, Ezumi MW, Faezahtul AH, Nurul AA. Phytochemical profiles and inhibitory effects of tiger milk mushroom (Lignosus rhinocerus) extract on ovalbumin-induced airway inflammation in a rodent model of asthma. BMC Comp Alt Med. 2016 Dec;16(1):167.

  10. Olaguibel JM, Quirce S, Julia B, Fernandez C, Fortuna AM, Molina J, Plaza V. Measurement of asthma control according to Global Initiative for Asthma guidelines: a comparison with the Asthma Control Questionnaire. Resp Res. 2012 Dec;13(1):50.

  11. Brand PL. Inhaled corticosteroids should be the first line of treatment for children with asthma. Paediatr Resp Rev. 2011 Dec 1;12(4):245-9.

  12. Chini L, Monteferrario E, Graziani S, Moschese V. Novel treatments of asthma and allergic diseases. Paediatr Resp Rev. 2014 Dec 1;15(4):355-62.

  13. Martin L. Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs. 2015 Aug;13(8):4784-98.

  14. Rengarajan T, Rajendran P, Nandakumar N, Balasu-bramanian M, Nishigaki I. Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis. Nutrients. 2013 Dec;5(12):4978-89.

  15. Chuyen HV, Eun JB. Marine carotenoids: Bioactivities and potential benefits to human health. Crit Rev Food Sci Nutr. 2017 Aug 13;57(12):2600-10.

  16. Zaharudin N, Staerk D, Dragsted LO. Inhibition of a-glucosidase activity by selected edible seaweeds and fucox-anthin. Food Chem. 2019 Jan 1;270:481-6.

  17. Gammone M, D'Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs. 2015;13(4): 2196-214.

  18. Zorofchian Moghadamtousi S, Karimian H, Khanabdali R, Razavi M, Firoozinia M, Zandi K, Abdul Kadir H. Anticancer and antitumor potential of fucoidan and fucox-anthin, two main metabolites isolated from brown algae. Sci World J. 2014;2014.

  19. Kumar S, Hosokawa M, Miyashita K. Fucoxanthin: marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs. 2013;11(12):5130-47.

  20. Hajrezaie M, Golbabapour S, Hassandarvish P, Gwaram NS, Hadi AH, Ali HM, Majid N, Abdulla MA. Acute toxicity and gastroprotection studies of a new schiff base derived copper (II) complex against ethanol-induced acute gastric lesions in rats. PLoS One. 2012 Dec 10;7(12):e51537.

  21. Kakkar P, Das B, Viswanathan PN. A modified spectro-photometric assay of superoxide dismutase. Ind J Biochem Biophys. 1984;21(2):130-2.

  22. Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952 Mar 1;195(1):133-40.

  23. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analy Biochem. 1968 Jan 1;25:192-205.

  24. Centers for Disease Control and Prevention. Chronic diseases: the leading causes of death and disability in the United States. 2015. Available from: https://www.cdc.gov/ chronicdisease/about/index.htm.

  25. Bhat YA, Rehman R, Mabalirajan U. Pathophysiology of asthma. Pathophysiology. 2017 Nov;5(X1).

  26. Bialas AJ, Sitarek P, Milkowska-Dymanowska J, Piotrowski WJ, Gorski P. The role of mitochondria and oxidative/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease. Oxidat Med Cel-lular Long. 2016;2016.

  27. MacNee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thoracic Soc. 2005 Apr;2(1):50-60.

  28. Lanza GM, Jenkins J, Schmieder AH, Moldobaeva A, Cui G, Zhang H, Yang X, Zhong Q, Keupp J, Sergin I, Paranandi KS. Anti-angiogenic nanotherapy inhibits airway remodeling and hyper-responsiveness of dust mite triggered asthma in the Brown Norway rat. Theranostics. 2017;7(2):377.

  29. Madigan LA, Gordon EM, Levine SJ, Druey KM, Wong G. Rgs4 attenuates allergen-induced airway hyper-responsiveness in mice. Am J Respir Crit Care Med. 2017;195:A5296.

  30. Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J. Autophagy plays a role in FSTL1-induced EMT and airway remodeling in asthma. Am J Physiol-Heart Circ Physiol. 2017 May 4:L27-40.

  31. Miyagawa M, Satou T, Yukimune C, Ishibashi A, Seimiya H, Yamada H, Hasegawa T, Koike K. Anxiolytic-like effect of illicium verum fruit oil, trans-anethole and related compounds in mice. Phytother Res. 2014 Nov;28(11):1710-2.

  32. He Y, Lou X, Jin Z, Yu L, Deng L, Wan H. Mahuang decoction mitigates airway inflammation and regulates IL-21/STAT3 signaling pathway in rat asthma model. J Ethnopharmacol. 2018 Oct 5;224:373-80.

  33. Matsuno T. Aquatic animal carotenoids. Fisheries Sci. 2001;67(5):771-83.


Articles with similar content:

Naringenin Ameliorates Doxorubicin Toxicity and Hypoxic Condition in Dalton's Lymphoma Ascites Tumor Mouse Model: Evidence from Electron Paramagnetic Resonance Imaging
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 3
Kumaresan Ganesan, Venkatesan Kathiresan, Murugesan Ramachandran, Swathika Subburaman, Mathivanan Natarajan, Arun Venkatesh Krishna, Gandhidasan Rathinasamy
Cytotoxicity of Blended Versus Single Medicinal Mushroom Extracts on Human Cancer Cell Lines: Contribution of Polyphenol and Polysaccharide Content
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 5
Jasna Franekic, Neven Jakopovich, Ivan Jakopovich, Drazenka Komes, Ksenija Durgo, Boris Jakopovic, Ana Belscak-Cvitanovic, Mladen Koncar
Effects of β-Lapachone on the Production of Th1 and Th2 Cytokines in C57BL/6 Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Kun-Young Park, Kwang Hyuk Kim, Jaehyun Ju, Myungwon Choi, Indal Park
Antiatherosclerotic Activity of Eriocitrin in High-Fat-Diet-Induced Atherosclerosis Model Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 1
Lingjuan Du, Shikui Guo, Yaoyu Feng, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Jia Wan
Thyroidal Effects of Di-(2-Ethylhexyl) Phthalate in Rats of Different Selenium Status
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Isabelle Hininger-Favier, Anne-Marie Roussel, Murat Kizilgun, Alain Favier, Belma Kocer-Gumusel, Filiz Hincal, Pinar Erkekoglu, Walid Rachidi