ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.241 5年インパクトファクター: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.50
pages 43-53

Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defense and chemically induced skin tumors

Priyanka Sharma
university of Rajasthan, jaipur, India
Jyoti Parmar
University of Rajasthan
Preeti Verma
JRF, Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan
Pradeep Kumar Goyal
Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur - 302 004, India

要約

The present study evaluates the modulatory potential of Phyllanthus niruri on chemically induced skin carcinogenesis and its influence on oxidative stress and the antioxidant defense system. Oral administration of P. niruri extract (PNE), during peri- (Gr. III), post- (Gr. IV) or peri- and post- (Gr. V) initiational stages of 7,12-dimethylbenz(a)anthracene (DMBA) / croton oil induced papillomagenesis considerably reduced tumor burden to 4.20, 4.00 and 3.33 (positive control value 6.20); cumulative number of papillomas to 21, 16 and 10 respectively (positive control value 62); and incidence of mice bearing papillomas to 50%, 40%, and 30%, respectively (positive control value 100%) but significantly increased the average latent period to 10.14, 10.62 and 11.60 and inhibition of tumor multiplicity to 66%, 74% and 83%respectively. Enzyme analysis of skin and liver showed a significant (p ≤ 0.05, ≤ 0.01, ≤ 0.001) elevation in antioxidant parameters such as superoxide dismutase, catalase, glutathione and vitamin C in PNE treated groups (Gr. III-V) when compared with the carcinogen treated control (Gr. II). The elevated level of lipid peroxidation in the carcinogen treated positive control group was significantly (p ≤ 0.05, ≤ 0.01, ≤ 0.001) inhibited by PNE administration. These results indicate that Phyllanthus niruri extract has potentiality to reduce skin papillomas by enhancing antioxidant defense system.


Articles with similar content:

Chemically Induced Skin Carcinogenesis in Mice and Its Prevention by Aegle marmelos (an Indian Medicinal Plant) Fruit Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Pradeep Kumar Goyal, Swafiya Jahan, Annapurna Agrawal
Chemopreventive Potential of an Indian Medicinal Plant (Tinospora cordifolia) on Skin Carcinogenesis in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 3
Pradeep Kumar Goyal, Ranu Chaudhary, Swafiya Jahan
Ameliorative Effect of Green Tea Catechin Against Cadmium Chloride−Induced Testicular Toxicity in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
Priyanka Sharma, Pradeep Kumar Goyal
Anti-Tumor Activity of Aloe vera Against DMBA/Croton Oil-Induced Skin Papillomagenesis in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
Pradeep Kumar Goyal, Geeta Chaudhary, M. R. Saini
Radioprotective Effect of Carvacrol Against X-Radiation−Induced Cellular Damage in Cultured Human Peripheral Blood Lymphocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 3
Nisha Susan Thomas, Thayalan Kuppusamy, Nalini Namashivayam, Sivaranjani Arivalagan