ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.241 5年インパクトファクター: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2015012006
pages 23-34

Lead Acetate-Induced Hepatoxicity in Wistar Rats: Possible Protective Role of Combination Therapy

Samta Sharma
Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior-474011, India
Suchita Raghuvanshi
Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior-474011, India
Amita Jaswal
Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior-474011, India
Sadhana Shrivastava
Reproductive Biology and Toxicology Labora¬tory, UNESCO Satellite Center of Trace Element Research, School of Studies in Zoology, Jiwaji University, Gwalior 474011, India
Sangeeta Shukla
School of Studies in Zoology, Jiwaji University, Gwalior 474011, India

要約

Experimental studies have shown that sulphur-containing antioxidants have beneficial effects against the detrimental properties of Pb. In the present study, we investigated the therapeutic potential of combined administration of N-acetyl cysteine (NAC; 50 mg/kg p.o.) and selenium (Se; 0.5 mg/kg p.o.) against lead acetate intoxication (Pb; 0.2% in water ad libitum) in a male rat model for 12 wk. The exposure of rats to lead acetate produced significant (P < 0.05) alterations in cytochrome P450 (CYP) activity, microsomal lipid peroxidation, reduced glutathione, and proteins. In addition, significant elevation in liver markers transaminases, triglycerides, cholesterol, and bilirubin as well as a decline in albumin were also compared with the experimental control rats. Combined treatment of lead-exposed animals with NAC and Se showed marked improvement of the biochemical, molecular, and histopathological findings. These experimental results strongly indicate the protective effect of NAC alone with Se against toxic effects of lead on liver tissue.


Articles with similar content:

Toxic Effects of Lead Exposure in Rats: Involvement of Oxidative Stress, Genotoxic Effect, and the Beneficial Role of N-Acetylcysteine Supplemented with Selenium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Samta Sharma, Bhanu Pratap Singh Raghuvanshi, Sangeeta Shukla
The Influence of Gingerol Treatment on Aluminum Toxicity in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 1
Sadhana Shrivastava
Reversal of Lead-Induced Acute Toxicity by Lipoic Acid with Nutritional Supplements in Male Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Sadhana Shrivastava, Yamini Sharma, Sangeeta Shukla
Heavy Metal−Induced Systemic Dysfunction Attenuated by Tannic Acid
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Pooja Sharma, Suhel Parvez, Heena Tabassum, Saima Khatoon, Dilruba Haque, Mohammad Ashafaq
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Mycelium Aqueous Extract Modulates High-Altitude–Induced Stress
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 5
Kshipra Misra, Jigni Mishra, Anuja Bhardwaj, Priyanka Sharma