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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Photoprotective Effect of Calluna vulgaris Extract Against UVB-Induced Phototoxicity in Human Immortalized Keratinocytes

巻 30, 発行 4, 2011, pp. 323-331
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i4.50
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要約

There is an increasing interest in the use of natural antioxidants as photoprotective agents against skin damages produced by ultraviolet radiation. The aim of our study was to investigate the protective effect of a Calluna vulgaris extract in human keratinocytes (HaCaT) exposed to ultraviolet B (UVB) radiation. HaCaT cells were treated with C. vulgaris extract 30 minutes prior to irradiation with UVB. The protective effect was evaluated by assessing cell viability using tetrasolium salt (MTT) assay; the generation of lipid peroxides was evaluated using malondialdehide assay (MDA); and DNA damage was evaluated using the comet assay and the quantification by ELISA of specific DNA photolesions [i.e., cyclobutane-pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs)]. After irradiation with cytotoxic doses of UVB (300 and 500 mJ/cm2), HaCaT cells pretreated with C. vulgaris extract (50 μg GAE/ml) showed significantly increased viability compared to control cells exposed to UVB only. Irradiation alone increased MDA levels in a dose-dependent fashion. Pretreatment with 12 μg GAE/ml extract lowered MDA levels both at 100 mJ/cm2 (ρ<0.01) and 300 mJ/cm2 (ρ<0.001). Treatment with C. vulgaris extract before exposure to UVB also reduced DNA damage: Lesion scores in a comet assay were significantly reduced at UVB doses of 50 mJ/cm2 (ρ<0.01) and 100 mJ/cm2 (ρ<0.05), while CPDs and 6-4PPs (via ELISA) were significantly lower after irradiation with 100 mJ/cm2 in the protected cells (ρ<0.05 for CPDs and ρ<0.001 for 6-4PPs). These results recommend the use of the C. vulgaris extract as photoprotective agent, in combination with sunscreens and/or other natural products with similar or complementary properties.

によって引用された
  1. Jang Jiyi, Ye Bo-Ram, Heo Soo-Jin, Oh Chulhong, Kang Do-Hyung, Kim Ji Hyung, Affan Abu, Yoon Kon-Tak, Choi Young-Ung, Park Se Chang, Han Seunghee, Qian Zhong-Ji, Jung Won-Kyo, Choi Il-Whan, Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes, Environmental Toxicology and Pharmacology, 34, 3, 2012. Crossref

  2. Ghedira K., Goetz P., Bruyère commune: Calluna vulgaris (L.) Hull. ou Calluna vulgáris Salisb. (Ericaceae), Phytothérapie, 11, 1, 2013. Crossref

  3. Decean H., Perde-Schrepler M., Tatomir C., Fischer-Fodor E., Brie I., Virag P., Modulation of the pro-inflammatory cytokines and matrix metalloproteinases production in co-cultivated human keratinocytes and melanocytes, Archives of Dermatological Research, 305, 8, 2013. Crossref

  4. Olteanu D., Baldea I., Clichici S., Bolfa P., Cenariu M., Schrepler-Perde M., Alupei M., Muresan A., Filip A., In vitro studies on the mechanisms involved in chemoprevention using Calluna vulgaris on vascular endothelial cells exposed to UVB, Journal of Photochemistry and Photobiology B: Biology, 136, 2014. Crossref

  5. Tamokou Jean de Dieu, Chouna Jean Rodolphe, Fischer-Fodor Eva, Chereches Gabriela, Barbos Otilia, Damian Grigore, Benedec Daniela, Duma Mihaela, Efouet Alango Pépin Nkeng, Wabo Hippolyte Kamdem, Kuiate Jules Roger, Mot Augustin, Silaghi-Dumitrescu Radu, Srivastava Rakesh K., Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants, PLoS ONE, 8, 2, 2013. Crossref

  6. Țigu Adrian Bogdan, Moldovan Cristian Silviu, Toma Vlad-Alexandru, Farcaș Anca Daniela, Moț Augustin Cătălin, Jurj Ancuța, Fischer-Fodor Eva, Mircea Cristina, Pârvu Marcel, Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study, Molecules, 26, 3, 2021. Crossref

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