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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Calcium Ameliorates Renal Cyst Growth in Metanephric Organ Culture: A Morphological Study

巻 31, 発行 3, 2012, pp. 285-293
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i3.90
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要約

Polycystic kidney disease (PKD) is associated with alterations in developmental processes that severely affect kidney integrity, often leading to fatal consequences. It has been suggested that dysfunctional calcium (Ca2+) regulation associated with the PKD phenotype is consequent to mutations affecting the pkd1 gene. Previously, it has been observed that blocking calcium along with cAMP allowed tubular epithelial cells to enter the proliferative phase that culminated in a cyst-like phenotype. In this regard, mouse metanephroi, (embryonic day 13.5, E13.5) were used to study morphological and ultrastructural effects of calcium replenishment on 8-bromocyclic 3'5'cyclic adenosine monophosphate (8-Br-cAMP)-induced cyst-like tubular dilations. Phase contrast microscopy of 8-Br-cAMP-treated metanephroi exhibited numerous dilated tubules that continued to increase in size for 4 days in culture. The effects of 8-Br-cAMP on renal tubular epithelia were assessed by histopathological and electron microscopic analyses. Transmission electron microscopy revealed changes such as increased vacuolation, swollen mitochondria, chromatin condensation, and disrupted cell membrane in tubular epithelia of 8-Br-cAMP-treated metanephroi. Concurrent treatments with calcium-channel agonists (calcium ionophore A23187 and phorbol-12-myristate-13-acetate) and 8-Br-cAMP abolished cAMP-induced morphometric and ultrastructural alterations. Calcium replenishment rescued tubular epithelial cells from mitogenic effects of cAMP and restored normal morphology at cellular and sub-cellular levels as verified by histopathological and ultrastructural examinations.

によって引用された
  1. Chebib Fouad T., Sussman Caroline R., Wang Xiaofang, Harris Peter C., Torres Vicente E., Vasopressin and disruption of calcium signalling in polycystic kidney disease, Nature Reviews Nephrology, 11, 8, 2015. Crossref

  2. Maser Robin L., Magenheimer Brenda S., Calvet James P., Metanephric organ culture, in Methods in Kidney Cell Biology - Part A, 153, 2019. Crossref

  3. Sussman Caroline R., Ward Christopher J., Leightner Amanda C., Smith Jordan L., Agarwal Reema, Harris Peter C., Torres Vicente E., Phosphodiesterase 1A Modulates Cystogenesis in Zebrafish, Journal of the American Society of Nephrology, 25, 10, 2014. Crossref

  4. Calvet James P., The Role of Calcium and Cyclic AMP in PKD, in Polycystic Kidney Disease, 2015. Crossref

  5. Irazabal Maria V., Chade Alejandro R., Eirin Alfonso, Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs, Clinical Science, 136, 5, 2022. Crossref

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