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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Photochemoprotective Effect of Calluna vulgaris Extract on Skin Exposed to Multiple Doses of Ultraviolet B in SKH-1 Hairless Mice

巻 31, 発行 3, 2012, pp. 233-243
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i3.50
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要約

UVB is a major cause of nonmelanoma skin cancer in humans. Photochemoprevention represents an important strategy in protecting the skin against the detrimental effects of ultraviolet B (UVB). We investigated the activity of Calluna vulgaris (Cv) delivered via a hydrogel on 3 main pathways (oxidative stress, inflammation, DNA damage) on skin exposed to multiple doses of UVB in SKH-1 mice. Fifty female mice were divided randomly into 5 groups: control, vehicle, UVB irradiated, Cv + UVB irradiated, and Cv + vehicle + UVB irradiated. The extract was applied topically on the skin in a dose of 4 mg polyphenols/cm2 30 minutes before each UVB (240 mJ/cm2) exposure over 10 consecutive days. Malondialdehyde, reduced glutathione, tumor necrosis factor-α, interleukin-6, cyclobutane pyrimidine dimer (CPD) levels, sunburn cell formation and epidermal thickness, and the number of epidermal cell layers in skin were evaluated 24 hours after the last treatment.
UVB increased cytokine levels (P < 0.001), formation of CPDs (P < 0.001) and sunburn cells (P < 0.001), and the epidermal thickness and number of epidermal cell layers (P < 0.001) compared with the control group. The topical application of Cv protected the skin against inflammation and DNA damage, as shown by a decreased number of CPDs (P < 0.001) and sunburn cells (P < 0.001). The administration of Cv via hydrogel may be a viable method for chemoprevention..

によって引用された
  1. Lorencini Márcio, Brohem Carla A., Dieamant Gustavo C., Zanchin Nilson I.T., Maibach Howard I., Active ingredients against human epidermal aging, Ageing Research Reviews, 15, 2014. Crossref

  2. Brohem Carla Abdo, Di Mambro Valéria Maria, Lorencini Márcio, Therapeutic Alternatives for the Treatment of Epidermal Aging, in Textbook of Aging Skin, 2017. Crossref

  3. Saric Suzana, Sivamani Raja, Polyphenols and Sunburn, International Journal of Molecular Sciences, 17, 9, 2016. Crossref

  4. Azqueta Amaya, Collins Andrew, Polyphenols and DNA Damage: A Mixed Blessing, Nutrients, 8, 12, 2016. Crossref

  5. Brohem Carla Abdo, Di Mambro Valéria Maria, Lorencini Márcio, Therapeutic Alternatives for the Treatment of Epidermal Aging, in Textbook of Aging Skin, 2015. Crossref

  6. Adamtsevich N. Yu., Feskova A. V., Leontiev V. N., Zhavoronok I. P., Yerofeyeva A.-M. V., Mankovskaya S. V., Titok V. V., Wound-healing effect of the gel substance based on the flavonoids complex from extracts of the everlasting(<i>Helichrysum arenarium</i> L.) and the littlewale (<i>Lithospermum officinale</i> L.), Proceedings of the National Academy of Sciences of Belarus, Biological Series, 67, 1, 2022. Crossref

  7. Kahan V., Ribeiro D.A., Egydio F., Barros L.A., Tomimori J., Tufik S., Andersen M.L., Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?, Skin Pharmacology and Physiology, 27, 3, 2014. Crossref

  8. Bolfa Pompei, Vidrighinescu Raluca, Petruta Andrei, Dezmirean Dan, Stan Laura, Vlase Laurian, Damian Grigore, Catoi Cornel, Filip Adriana, Clichici Simona, Photoprotective effects of Romanian propolis on skin of mice exposed to UVB irradiation, Food and Chemical Toxicology, 62, 2013. Crossref

  9. Cucu Alexandra-Antonia, Baci Gabriela-Maria, Cucu Alexandru-Bogdan, Dezsi Ştefan, Lujerdean Cristian, Hegeduş Iuliana Cristina, Bobiş Otilia, Moise Adela Ramona, Dezmirean Daniel Severus, Calluna vulgaris as a Valuable Source of Bioactive Compounds: Exploring Its Phytochemical Profile, Biological Activities and Apitherapeutic Potential, Plants, 11, 15, 2022. Crossref

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