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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Photochemical Internalization (PCI): A New Modality for Light Activation of Endocytosed Therapeuticals

巻 25, 発行 1-2, 2006, pp. 521-536
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.330
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要約

Photochemical internalization (PCI) is a new technology, where certain photosensitizing substances (photosensitizers) are used to improve the utilization of macromolecules for cancer therapy, in a site-specific manner. Degradation of macromolecules in endocytic vesicles after uptake by endocytosis is a major intracellular barrier for the therapeutic application of molecules having intracellular targets of action. PCI is based on the light activation of photosensitizers specifically located in the membrane of endocytic vesicles inducing the rupture of this membrane upon illumination. Thereby endocytosed molecules can be released to reach their target of action before being degraded in lysosomes. This has been shown to enhance the biological activity of a large variety of macromolecules and other molecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins (RIPs), immunotoxins, gene-encoding plasmids, adenovirus, peptidenucleic acids, and the chemotherapeuticum bleomycin. In several cases up to a 100-fold increase in biological activity has been observed. This article reviews the background and present status of PCI.

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  1. Juzeniene Asta, Moan Johan, The history of PDT in Norway, Photodiagnosis and Photodynamic Therapy, 4, 2, 2007. Crossref

  2. Jin Honglin, Lovell Jonathan F., Chen Juan, Ng Kenneth, Cao Weiguo, Ding Lili, Zhang Zhihong, Zheng Gang, Cytosolic delivery of LDL nanoparticle cargo using photochemical internalization, Photochemical & Photobiological Sciences, 10, 5, 2011. Crossref

  3. Norum Ole-Jacob, Selbo Pål Kristian, Weyergang Anette, Giercksky Karl-Erik, Berg Kristian, Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine, Journal of Photochemistry and Photobiology B: Biology, 96, 2, 2009. Crossref

  4. Bonneau Stéphanie, Vever-Bizet Christine, Mojzisova Halina, Brault Daniel, Tetrapyrrole-photosensitizers vectorization and plasma LDL: A physico-chemical approach, International Journal of Pharmaceutics, 344, 1-2, 2007. Crossref

  5. Gillmeister Michael P., Betenbaugh Michael J., Fishman Paul S., Cellular Trafficking and Photochemical Internalization of Cell Penetrating Peptide Linked Cargo Proteins: A Dual Fluorescent Labeling Study, Bioconjugate Chemistry, 22, 4, 2011. Crossref

  6. Weyergang Anette, Kaalhus Olav, Berg Kristian, Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival, Molecular Cancer Therapeutics, 7, 6, 2008. Crossref

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