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Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Regulation of Porphyrin Synthesis and Photodynamic Therapy in Heavy Metal Intoxication

巻 25, 発行 1-2, 2006, pp. 145-158
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.80
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要約

Protoporphyrin IX (PpIX) synthesis by malignant cells is successfully exploited for photodynamic therapy (PDT) following administration of 5-aminolevulinic acid (ALA) and light irradiation. The influence of two environmental heavy metal poisons, lead and gallium, on PpIX-synthesis and ALA-PDT was studied in two neu-ronal cell lines, SH-SY5Y neuroblastoma and PC12 pheochromocytoma. The heavy metal intoxication affected two of the heme-synthesis enzymes, ALA-dehydratase (ALAD) and porphobilinogen deaminase (PBGD). The present results show that lead poisoning significantly decreased the PBGD cellular level and inhibited its enzymatic activity, whereas the effects of gallium were less prominent. Although, the protein levels were reduced, the mRNA levels of PBGD remained unchanged during metal intoxication. These findings show additional inhibitory activity of lead on top of its classical effect on ALAD. Proteasome activity was enhanced during lead treatment, as measured by the AMC fluorigenic proteasome assay. The reduction in PBGD levels was not a consequence of PBGD mRNA reduced synthesis, which remained unchanged as shown by RT-PCR analysis. As a result of the lead poisoning, marked alterations in the cell cycle were observed, including a decreased G1 phase and an increased number of S phase cells. The efficacy of ALA-PDT was reduced in correlation with decreased activities of the enzymes during lead intoxication. We may conclude that lead poisoning adversely affects the outcome of ALA photodynamic therapy of cancer.

によって引用された
  1. Feuerstein Tamar, Schauder Avital, Malik Zvi, Silencing of ALA dehydratase affects ALA-photodynamic therapy efficacy in K562 erythroleukemic cells, Photochemical & Photobiological Sciences, 8, 10, 2009. Crossref

  2. Grünberg-Etkovitz Nurit, Greenbaum Lior, Grinblat Borislava, Malik Zvi, Proteasomal degradation regulates expression of porphobilinogen deaminase (PBGD) mutants of acute intermittent porphyria, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1762, 9, 2006. Crossref

  3. Ohgari Yoshiko, Miyata Yoshinobu, Miyagi Taeko, Gotoh Saki, Ohta Takano, Kataoka Takao, Furuyama Kazumichi, Taketani Shigeru, Roles of Porphyrin and Iron Metabolisms in the δ-Aminolevulinic Acid (ALA)-induced Accumulation of Protoporphyrin and Photodamage of Tumor Cells, Photochemistry and Photobiology, 87, 5, 2011. Crossref

  4. Schauder Avital, Feuerstein Tamar, Malik Zvi, The centrality of PBGD expression levels on ALA-PDT efficacy, Photochemical & Photobiological Sciences, 10, 8, 2011. Crossref

  5. Rabinovich O. F., Guseva A. V., Abramova E. S., Clinical and laboratory rationale for photodynamic therapy in patients with severe complicated oral lichen planus, Stomatologiya, 94, 2, 2015. Crossref

  6. Wachowska Małgorzata, Muchowicz Angelika, Firczuk Małgorzata, Gabrysiak Magdalena, Winiarska Magdalena, Wańczyk Małgorzata, Bojarczuk Kamil, Golab Jakub, Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer, Molecules, 16, 5, 2011. Crossref

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