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Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.241 5年インパクトファクター: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.10
pages 1-6

Oxidative Stress−Mediated Apoptotic Death in Human Peripheral Blood Lymphocytes Treated with Plasma from Gamma-Irradiated Blood

R. Vasumathy
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Badri Narain Pandey
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Kaushala Prasad Mishra
Department of Life Sciences, University of Mumbai, Mumbai, India; Nehru Gram Bharati University, Allahabad, UP, India; Foundation for Education and Research, India and BM International Research Centre, Mumbai, India

要約

The present study is aimed to investigate the effect of plasma from irradiated human blood on the induction of apoptotic death in human peripheral blood lymphocytes. Our results showed that plasma obtained from γ-irradiated human blood showed a significant decrease in viability and an increase in apoptotic death in unirradiated lymphocytes, which is correlated with increase in intracellular reactive oxygen species level. Moreover, a decrease in the activity of superoxide dismutase in lymphocytes further seems to be associated with oxidative stress−mediated apoptotic death. The diffusible factors from irradiated blood were found to be generated from the cellular components of blood. Based on our results, we suggest induction of oxidative stress−mediated apoptotic death in unirradiated lymphocytes by diffusible factors from irradiated blood.


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