ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.241 5年インパクトファクター: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v22.i1.60
10 pages

Studies on Correlation of Antimutagenic and Antiproliferative Activities of Juglans regia L.

Kamaljit Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India
Husheem Michael
Department of Anatomy, ! e Institute of Biomedicine, University of Turku, Turku, Finland
Saroj Arora
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, Punjab, India
Pirkko L. Harkonen
Department of Anatomy, ! e Institute of Biomedicine, University of Turku, Turku, Finland
Subodh Kumar
Department of Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India

要約

We investigated the effect of water and acetone extract of Juglans regia L. to evaluate its antimutagenic and antiproliferative activities. The antimutagenic study using TA98 and TA100 tester strains of Salmonella revealed the water and acetone extracts to be more effective than the benzene and chloroform extracts in inhibiting the revertants induced by 2–aminoflourene (2AF) in TA100 tester strains. The most effective extracts in the Ames assay were further evaluated using the Lucifer luciferase assay and in time course studies for antiproliferative activities using the Hoechst staining to observe apoptotic cell deaths. The acetone extract showed a correlation of antimutagenic activities in the Ames assay with its antiproliferative effect in different cell lines, while the water extract exerted its effect distinctly in each cell line. Further studies are still needed to evaluate the cytotoxicity in experiments carried out in vivo.


Articles with similar content:

Bioassay-Guided Isolation of Antimutagenic Factors from Fruits of Terminalia Bellerica
Journal of Environmental Pathology, Toxicology and Oncology, Vol.22, 2003, issue 1
Saroj Arora, Swayamjot Kaur, Subodh Kumar, Satwinderjeet Kaur
The Effect of Culture Liquid Ethyl Acetate Mycelium Extracts of Medicinal Mushrooms on the Viability of Human Pancreatic Cancer Cells
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 2
Solomon P. Wasser, Lital E. Sharvit, Fuad Fares
Cytotoxic Activities of Fractions of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes), and the Induction of Cell Cycle Arrest and Apoptosis in MGC-803 Cells
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 6
Fei-Fei Wang, Wei Ma, Ning Li , Feng Liu, Chao Shi, Kai-Jin Wang
Evaluation of Antibacterial and Anticancer Activities of the Medicinal Fungus Ophiocordyceps sobolifera (Ascomycetes) from Thailand
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 5
Sasithorn Thongchai, Benjaporn Buranrat, Piyanoot Jaihan, Aphidech Sangdee, Kusavadee Sangdee
Diverse Effects of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Combination with Tamoxifen Citrate and Doxorubicin in MCF-7 Breast Cancer Cells
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 6
Sevcan Atay, Erbil Kalmis, Handan Ak, Husniye Kayalar, Hikmet Hakan Aydin