ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Environmental Pathology, Toxicology and Oncology
インパクトファクター: 1.241 5年インパクトファクター: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v24.i4.80
pages 315-332

Radioprotection by Oral Administration of Aegle marmelos (L.) Correa In Vivo

Ganesh Chandra Jagetia
Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
Ponemone Venkatesh
Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India

要約

The radioprotective effect of an extract of Aegle marmelos (L.) Correa (AME), family Rutaceae, was investigated in mice exposed to different doses of γ-radiation. Mice were administered orally AME 250 mg/kg b.wt. orally daily for 5 consecutive days before exposure to 6, 7, 8, 9, 10, or 11 Gy of γ-radiation. The animals were monitored daily up to 30 days after irradiation for the development of symptoms of radiation sickness or death. Treatment of mice with AME before irradiation reduced the symptoms of radiation sickness and delayed death compared to the irradiated controls given sterile physiological saline (SPS). AME provided protection against both gastrointestinal and hematopoietic toxicities. Reducing the administration schedule of AME to 1 or 3 consecutive days or increasing the schedule to 7 consecutive days was not as effective as 5 consecutive days of preradiation schedule. The administration of AME after irradiation was not effective, and no survivors could be reported 30 days after irradiation. The LD50/30 was found to be 8.1 Gy for the SPS + irradiation group and 9.7 Gy for the AME + irradiation group. The oral administration of AME resulted in an increase in radiation tolerance by 1.6 Gy, and the dose reduction factor was found to be 1.2. Preradiation treatment of mice with AME caused a significant depletion in lipid peroxidation followed by a significant elevation in glutathione concentration in the liver of mice 31 days after irradiation. The drug was nontoxic up to a dose of 6000 mg/kg b.wt., the highest drug dose that could be tested for acute toxicity.


Articles with similar content:

Radioprotective Potential of Rosemarinus officinalis against Lethal Effects of Gamma Radiation : A Preliminary Study
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 4
Dhanraj Soyal, Pradeep Kumar Goyal, Archana Jindal, Garima Sancheti
Acute Toxicity Effects of Prunus avium Fruit Extract and Selection of Optimum Dose Against Radiation Exposure
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 4
Smita Singh, K. V. Sharma, Rashmi Sisodia
Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 1
Smita Singh, Ekta Meghnani, Preeti Srivastava, Rashmi Sisodia, chaturbhuj Mundotiya
Radioprotective Effects of Aloe Vera Leaf Extract on Swiss Albino Mice against Whole-Body Gamma Irradiation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 1
Pradeep Kumar Goyal, Prashasnika Gehlot
Effects of Aegle marmelos (L.) Correa on the Peripheral Blood and Small Intestine of Mice Exposed to Gamma Radiation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 4
Ponemone Venkatesh, Parampally Archana, Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga, Bhandarkar R. Krishnanand