年間 4 号発行
ISSN 印刷: 2572-4258
ISSN オンライン: 2572-4266
IF:
1.3
5-Year IF:
1.7
Immediacy Index:
0.7
Eigenfactor:
0.00023
JCI:
0.11
SJR:
0.244
SNIP:
0.521
CiteScore™::
3.6
H-Index:
14
Indexed in
BIOSAFETY AND EFFECT OF NANOPARTICLES OF CeO2 ON METABOLIC AND PROLIFERATIVE ACTIVITY OF HUMAN MESENCHYMAL STEM CELLS IN VITRO
Get access
要約
Clinical use of mesenchymal stem cells (MSCs) provides new prospects for treatment of most socially significant human diseases. Meanwhile, today there exist certain restrictions and difficulties in using MSCs for biomedical purposes. One of the restrictions for broad application of MSCs in cell therapy is their low proliferation rate in vitro, which increases the patient's waiting time for such treatment and, ultimately, its cost. Therefore, the search for new efficient and safe stimulators of MSC proliferation represents an urgent problem. In this work, we investigated the effect of cerium oxide (CeO2) nanoparticles on proliferative activity of human MSCs derived from human dental pulp. It was demonstrated that CeO2 nanoparticles are not toxic for human MSCs and increase their proliferation rate in vitro, simulating the level of expression of a broad range of genes responsible for the processes of proliferation, differentiation, and the cell cycle.
-
Popov Anton L., Zholobak Nadia M., Shcherbakov Alexander B., Kozlova Taisiya O., Kolmanovich Danil D., Ermakov Artem M., Popova Nelli R., Chukavin Nikita N., Bazikyan Ernest A., Ivanov Vladimir K., The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells, Nanomaterials, 12, 17, 2022. Crossref