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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN 印刷: 2151-8017
ISSN オンライン: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2012006115
pages 141-154

Nitrosothiol Signaling in Anoikis Resistance and Cancer Metastasis

Sudjit Luanpitpong
Department of Pharmaceutical Sciences, Hampton University, Hampton, Virginia
Anand Krishnan V. Iyer
Department of Pharmaceutical Sciences, School of Pharmacy, Hampton University, Hampton, Virginia
Neelam Azad
Department of Pharmaceutical Sciences, School of Pharmacy, Hampton University, Hampton, Virginia
Liying Wang
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia
Yon Rojanasakul
Department of Pharmaceutical Sciences, Hampton University, Hampton, Virginia; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia

要約

Nitric oxide (NO) has been widely recognized as an important cell-signaling molecule that regulates various physiological and pathological processes. S-nitrosylation, or covalent attachment of NO to protein sulfhydryl groups, is a key mechanism by which NO regulates protein functions and cellular processes. In this article we discuss the various roles of NO and protein nitrosylation in cancer development, with a focus on cell invasion and anoikis resistance, both of which are key determinants of cancer metastasis. We specially address some of the mechanisms by which NO-mediated S-nitrosylation modulates substrates that have putative effects on key steps of metastasis. We propose that nitrosothiol signaling is a key regulatory mechanism common to several pathways involved in cancer progression and metastasis, and identifying such a mechanism will improve our understanding of the disease process and aid in the development of novel anticancer therapeutics.


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