年間 4 号発行
ISSN 印刷: 1050-6934
ISSN オンライン: 1940-4379
Indexed in
Clinical Analysis of Statistical Data on the Characteristics of Patients with Acute Respiratory Distress Syndrome in a Greek ICU
要約
Acute respiratory distress syndrome (ARDS) is a potentially life-threatening condition for a many patients. The associated mortality rate may exceed 50% in some cases. The etiopathogenesis of the syndrome remains unclear, and in Greece the exact number of people suffering or dying of ARDS each year is unknown. In this study, we sought to record the clinical characteristics and outcomes of all patients with laboratory confirmed ARDS. This is a retrospective single-center observational study, conducted in mixed, closed-type ICU with 12 beds at a Greek public health system hospital. The medical records of patients admitted to the ICU from January 1, 2015, until December 31, 2016, were retrospectively studied, and statistical analyses were performed using SPSS version 22.0 software. Patients were assessed using the Fisher exact test assuming variances. All tests were two-tailed. In total, 15 patients developed ARDS (5.4%). According to the existence of radiographic pulmonary edema image with bilateral infiltrates, 12 patients were classified in the early phase of the syndrome described by the term exudative phase and 3 patients were classified in the third stage of final fibrosis (fibrotic stage). According to the Fisher test, there is a significant correlation between age and outcome. The incidence of the syndrome among hospitalized patients in ICU is in line with the current literature, while the main predisposing factor in this study was acute pancreatitis.
-
Matthay M. , Acute respiratory distress syndrome. In: Matthay M. Lung biology in health and disease. New York: Dekker; 2003. p. 179.
-
Buford TH, Burbank B. , Traumatic wet lung. J Thoracic Surg. 1945;14:415–24.
-
Villar J, Blanco J, Añón JM, Santos-Bouza A, Blanch L, Ambrós A, Gandía F, Carriedo D, Mosteiro F, Basaldúa S, Fernández RL., The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med. 2011;37(12):1932–41.
-
Iscimen R, Cartin-Ceba R, Yilmaz M, Cartin-Ceba R, Hubmayr R, Afessa B, Gajic O, Farmer J., Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study. Crit Care Med. 2008;36(5):1518–22.
-
Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. , Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med. 2005;33(6):1191–98.
-
Goss CH, Brower RG, Hudson LD, Rubenfeld GD. , ARDS Network. Incidence of acute lung injury in the United States. Crit Care Med. 2003;31(6):1607–11.
-
The ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012; 2016 Mar-Apr;35(2):59–62.
-
Walkey AJ, Summer R, Ho V, Alkana P. , Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol. 2012;4:159–69.
-
Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M. , Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685–93.
-
Luhr OR, Antonsen K, Karlsson M. , Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. The ARF Study Group. Am J Respir Crit Care Med. 1999;159(6):1849–61.
-
Bersten AD, Edibam C, Hunt T, Moran J. , Austarlian and New Zealand Intensive Care Society clinical trials group. incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian states. Am J Respir Crit Care Med. 2002;165:443–48.
-
Gajic O, Afessa B, Thompson BT, Frutos-Vivar F, Malinchoc M, Rubenfeld GD, Esteban A, Anzueto A, Hubmayr RD. , Prediction of death and prolonged mechanical ventilation in acute lung injury. Crit Care. 2007;11(3):R53.
-
Igic R, Behnia R. , Properties and distribution of angiotensin I converting enzyme. Curr Pharm Des. 2003;9:697–706. DOI: 10.2174/1381612033455459
-
Moss M, Bucher B, Moore FA, Moore EE, Parsons PE. , The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA. 1996;275(1):50–54.
-
Hua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM, Scales DC, Stather DR, Li A, Jones A, Gattas DJ., Has mortality from acute respiratory distress syndrome decreased over time? Asystematic review. Am J Respir Crit Care Med. 2009;179:220–27.