ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Journal of Long-Term Effects of Medical Implants
SJR: 0.133 SNIP: 0.491 CiteScore™: 0.89

ISSN 印刷: 1050-6934
ISSN オンライン: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v12.i4.20
20 pages

Phosphorylcholine-Coated Stents

Andrew L. Lewis
Biocompatibles Ltd., Farnham Business Park, Weydon Lane, Farnham, Surrey, GU9 8QL, UK
Peter W. Stratford
Biocompatibles Ltd., Farnham, Surrey, UK

要約

Stainless steel stents have been developed to perform their primary purpose of providing sufficient physical support to an artery following percutaneous transluminal coronary angioplasty (PTCA) in order to prevent vessel recoil. Early clinical problems, largely caused by subacute thrombosis (SAT), have been significantly reduced with a new generation of antiplatelet agents. Despite improved pharmacological control of SAT in many patients, the potential for stent occlusion remains a life-threatening problem for those with more complex lesions. One strategy for dealing with this is to improve the hemocompatibility of the stent surface with coatings. A phosphorylcholine (PC)-based stent coating has been designed for this purpose; we describe in detail the evaluation of the device, in vitro, through preclinical and early clinical data. We discuss studies that demonstrate that the PC-coated stent may offer some clinical advantage over uncoated counterparts. The extensive experience with this PC-coated device supports its nonthrombogenic nature, excellent acceptance by arterial tissue, and long-term stability in vivo. These characteristics, together with its ability to load and release a variety of therapeutic agents, also make the device a natural choice of platform for future stent- mediated drug delivery for treating restenosis.


Articles with similar content:

A Review on Phosphorylcholine-Coated Stents
Journal of Long-Term Effects of Medical Implants, Vol.27, 2017, issue 2-4
Andrew L. Lewis, Peter W. Stratford
Drug-Coated Percutaneous Balloon Catheters
Critical Reviews™ in Biomedical Engineering, Vol.42, 2014, issue 3-4
Jayesh V. Betala, Eugene M. Langan III, jayesh betala
Therapeutic Angiogenesis: A Case for Targeted, Regulated Gene Delivery
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
Keith A. Webster
Are Microfluidics-Based Blood Viscometers Ready for Point-of-Care Applications? A Review
Critical Reviews™ in Biomedical Engineering, Vol.38, 2010, issue 2
Peng Kai Ong, Sangho Kim, Dohyung Lim
Stent-Based Gene Therapy
Journal of Long-Term Effects of Medical Implants, Vol.10, 2000, issue 1&2
James Ft. Kneller, Bo Sun, Michael L. Reed, Harvey S. Borovetz, Bryan J. Koci, Clarence C. Wu, Ahmed Nadeem, Marc D. Feldman, A. J. Conrad Smith, Warren D. Rosenblum, Lee E. Weiss, Simon Watkins