年間 4 号発行
ISSN 印刷: 1050-6934
ISSN オンライン: 1940-4379
Indexed in
Factors Influencing the Long-Term Behavior of Extracellular Matrix-Derived Scaffolds for Musculoskeletal Soft Tissue Repair
要約
Musculoskeletal connective tissues such as tendon, ligament, and cartilage possess a limited ability for self-repair. Tissue engineering seeks to use combinations of cells, bioactive molecules, and biomaterials to develop new treatment options for the repair or replacement of damaged tissues. The use of native extracellular matrix as scaffold material for tissue engineering has become increasingly attractive because such tissues can not only provide structural support, but also regulate cell behavior. Although demineralized bone matrix has long been recognized for its osteoinductive abilities, recent studies have identified the ability of cartilage and tendon extracellular matrices to stimulate the differentiation of mesenchymal or adipose-derived adult stem cells toward chondrogenic or tenogenic lineages, respectively. This review discusses the motivation for fabricating scaffolds from musculoskeletal tissues, the in vitro and in vivo efficacy of these tissue-derived scaffolds, and various processing techniques such as decellularization or cross-linking that can mitigate immunogenic responses, moderate the degradation profile, and enhance the mechanical properties of these constructs following long-term implantation in vivo.
-
Chainani Abby, Hippensteel Kirk J., Kishan Alysha, Garrigues N. William, Ruch David S., Guilak Farshid, Little Dianne, Multilayered Electrospun Scaffolds for Tendon Tissue Engineering, Tissue Engineering Part A, 19, 23-24, 2013. Crossref
-
Smith Benjamin D., Grande Daniel A., The current state of scaffolds for musculoskeletal regenerative applications, Nature Reviews Rheumatology, 11, 4, 2015. Crossref
-
Chainani Abby, Little Dianne, Current Status of Tissue-engineered Scaffolds for Rotator Cuff Repair, Techniques in Orthopaedics, 31, 2, 2016. Crossref
-
Yang Jie-Liang, Yao Xuan, Qing Quan, Zhang Yi, Jiang Yan-Lin, Ning Liang-Ju, Luo Jing-Cong, Qin Ting-Wu, An engineered tendon/ligament bioscaffold derived from decellularized and demineralized cortical bone matrix, Journal of Biomedical Materials Research Part A, 106, 2, 2018. Crossref
-
Singh Deepti, Zo Sun Mi, Singh Dolly, Han Sung Soo, Interpenetrating alginate on gelatin–poly(2-hydroxyethyl methacrylate) as a functional polymeric matrix for cartilage tissue engineering, International Journal of Polymeric Materials and Polymeric Biomaterials, 68, 10, 2019. Crossref
-
Sartika Dewi, Wang Chih-Hsin, Wang Ding-Han, Cherng Juin-Hong, Chang Shu-Jen, Fan Gang-Yi, Wang Yi-Wen, Lee Chian-Her, Hong Po-Da, Wang Chih-Chien, Human Adipose-Derived Mesenchymal Stem Cells-Incorporated Silk Fibroin as a Potential Bio-Scaffold in Guiding Bone Regeneration, Polymers, 12, 4, 2020. Crossref
-
Vasiliadis Angelo V., Katakalos Konstantinos, The Role of Scaffolds in Tendon Tissue Engineering, Journal of Functional Biomaterials, 11, 4, 2020. Crossref
-
Barceló Xavier, Eichholz Kian F., Garcia Orquidea, Kelly Daniel J., Tuning the Degradation Rate of Alginate-Based Bioinks for Bioprinting Functional Cartilage Tissue, Biomedicines, 10, 7, 2022. Crossref