年間 4 号発行
ISSN 印刷: 2694-4642
ISSN オンライン: 2694-4650
Indexed in
S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor−Negative Breast Cancer
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要約
Chronic inflammation within the tumor microenvironment is a major driver of tumor progression and poor prognosis. Inducible nitric oxide synthase (NOS2) is present in numerous solid tumors. Estrogen receptor−negative (ER-) patients with high expression of tumor NOS2 have a poorer outcome than patients with low expression of NOS2. Furthermore, expression of NOS2 is associated with the basal-like breast cancer phenotype. Using an in vitro model, we have found that nitrosation of critical thiols and nitration of tyrosines lead to the activation of membrane receptors such as epithelial growth factor receptor, Src, Ras, and CD63. These nitric oxide−mediated events in itiate oncogenic signaling pathways such as PI3K/Akt, Ras/ERK, β-catenin, nuclear factor-κÂ, and AP-1. These data suggest that NOS2 can serve as a major "nonmutatational driver" of ER- breast cancer.
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Basudhar Debashree, Somasundaram Veena, de Oliveira Graciele Almeida, Kesarwala Aparna, Heinecke Julie L., Cheng Robert Y., Glynn Sharon A., Ambs Stefan, Wink David A., Ridnour Lisa A., Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression, Antioxidants & Redox Signaling, 26, 18, 2017. Crossref
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Guequén Anita, Zamorano Patricia, Córdova Francisco, Koning Tania, Torres Angelo, Ehrenfeld Pamela, Boric Mauricio P., Salazar-Onfray Flavio, Gavard Julie, Durán Walter N., Quezada Claudia, Sarmiento José, Sánchez Fabiola A., Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells, Frontiers in Physiology, 10, 2019. Crossref
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McGinity Christopher L., Palmieri Erika M., Somasundaram Veena, Bhattacharyya Dibyangana D., Ridnour Lisa A., Cheng Robert Y. S., Ryan Aideen E., Glynn Sharon A., Thomas Douglas D., Miranda Katrina M., Anderson Stephen K., Lockett Stephen J., McVicar Daniel W., Wink David A., Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment, International Journal of Molecular Sciences, 22, 13, 2021. Crossref
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Ibáñez-Vea María, Huang Honggang, Martínez de Morentin Xabier, Pérez Estela, Gato Maria, Zuazo Miren, Arasanz Hugo, Fernández-Irigoyen Joaquin, Santamaría Enrique, Fernandez-Hinojal Gonzalo, Larsen Martin R., Escors David, Kochan Grazyna, Characterization of Macrophage Endogenous S-Nitrosoproteome Using a Cysteine-Specific Phosphonate Adaptable Tag in Combination with TiO2 Chromatography, Journal of Proteome Research, 17, 3, 2018. Crossref
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Sengupta Rajib, Coppo Lucia, Sircar Esha, Mishra Pradeep, Holmgren Arne, S‐Denitrosylation by the C‐Terminal Swinging Arm of R1 Subunit: A Novel Mechanism to Restore Ribonucleotide Reductase Activity, ChemistrySelect, 6, 8, 2021. Crossref
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