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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Heavy-Chain-Only Antibody Expression and B-Cell Development in the Mouse

巻 26, 発行 5, 2006, pp. 377-390
DOI: 10.1615/CritRevImmunol.v26.i5.10
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要約

Antibodies expressed in mice, humans, and most mammals consist of paired heavy (H) and light (L) chains. Cellular release of single H-chains without L-chains is prevented by chaperone association and retention in the endoplasmic reticulum. Consequently, H-chain-only antibodies are absent, except in pathological conditions known as Heavy Chain Disease, where they occur in mutated form. An exception to this is found in the serum of Camelidae. Homodimeric H-chain antibodies in camelids lack the first constant region domain (CH1) of the H-chain but retain an otherwise intact H-chain polypeptide, thus maintaining antigen specificity and effector functions. In this review, we summarize how H-chain antibodies can be expressed in mice, and whether normal developmental processes leading to antibody expression without L-chain are retained.

によって引用された
  1. Muyldermans S., Baral T.N., Retamozzo V. Cortez, De Baetselier P., De Genst E., Kinne J., Leonhardt H., Magez S., Nguyen V.K., Revets H., Rothbauer U., Stijlemans B., Tillib S., Wernery U., Wyns L., Hassanzadeh-Ghassabeh Gh., Saerens D., Camelid immunoglobulins and nanobody technology, Veterinary Immunology and Immunopathology, 128, 1-3, 2009. Crossref

  2. Zou Xiangang , Osborn Michael J. , Bolland Daniel J. , Smith Jennifer A. , Corcos Daniel , Hamon Maureen , Oxley David , Hutchings Amanda , Morgan Geoff , Santos Fatima , Kilshaw Peter J. , Taussig Michael J. , Corcoran Anne E. , Brüggemann Marianne , Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice , Journal of Experimental Medicine, 204, 13, 2007. Crossref

  3. Zou Xiangang, Smith Jennifer A., Corcos Daniel, Matheson Louise S., Osborn Michael J., Brüggemann Marianne, Removal of the BiP-retention domain in Cμ permits surface deposition and developmental progression without L-chain, Molecular Immunology, 45, 13, 2008. Crossref

  4. Steeland Sophie, Vandenbroucke Roosmarijn E., Libert Claude, Nanobodies as therapeutics: big opportunities for small antibodies, Drug Discovery Today, 21, 7, 2016. Crossref

  5. Huang Lieven, De Baetselier Patrick, Beyaert Rudi, Targeting the EGF receptor ectodomain in the context of cancer, Expert Opinion on Therapeutic Targets, 13, 11, 2009. Crossref

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