ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2017019158
pages 283-314

The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease

Veronica M. Ringel-Scaia
Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061
Dylan K. McDaniel
Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061
Irving C. Allen
Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061; Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061

要約

Recent advances have revealed significant insight into inflammatory bowel disease (IBD) pathobiology. Ulcerative colitis and Crohn's disease, the chronic relapsing clinical manifestations of IBD, are complex disorders with genetic and environmental influences. These diseases are associated with the dysregulation of immune tolerance, excessive inflammation, and damage to the epithelial cell barrier. Increasing evidence indicates that pattern recognition receptors, including Toll-like receptors (TLRs) and nucleotide-binding domain and leucine-rich repeat-containing proteins (NLRs), function to maintain immune system homeostasis, modulate the gastrointestinal microbiome, and promote proper intestinal epithelial cell regeneration and repair. New insights have revealed that NLR family members are essential components in maintaining this immune system homeostasis. To date, the vast majority of studies associated with NLRs have focused on family members that form a multiprotein signaling platform called the inflammasome. These signaling complexes are responsible for the cleavage and activation of the potent pleotropic cytokines IL-1β and IL-18, and they facilitate a unique form of cell death defined as pyroptosis. In this review, we summarize the current paradigms associated with NLR inflammasome maintenance of immune system homeostasis in the gastrointestinal system. New concepts related to canonical and noncanonical inflammasome signaling, as well as the implications of classical and alternative inflammasomes in IBD pathogenesis, are also reviewed.


Articles with similar content:

The Inflammasome and Its Regulation
Critical Reviews™ in Immunology, Vol.34, 2014, issue 1
Hideki Hara, Kohsuke Tsuchiya
Role of Macrophages in the Biological Reaction to Wear Debris from Joint Replacements
Journal of Long-Term Effects of Medical Implants, Vol.24, 2014, issue 4
Stuart B. Goodman, Christophe Nich
The Role of Macrophages in the Biological Reaction to Wear Debris from Artificial Joints
Journal of Long-Term Effects of Medical Implants, Vol.26, 2016, issue 4
Jiri Gallo, Stuart B. Goodman, Yuya Takakubo, Michiaki Takagi, Christophe Nich, Jukka Pajarinen, Yrjo T. Konttinen
Mast Cell Homeostasis: A Fundamental Aspect of Allergic Disease
Critical Reviews™ in Immunology, Vol.27, 2007, issue 1
Kelly Speiran, Brian Barnstein, John J. Ryan, Carole Oskeritzian, Jennifer Brenzovich, Daniel Bailey, Sarah Kennedy, Mohit Kashyap, Gregorio Gomez
Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease
Critical Reviews™ in Immunology, Vol.32, 2012, issue 1
Shankar Subramanian Iyer, Gehong Cheng