年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System
要約
Originally described as a T lymphocyte-derived factor that inhibited the random migration of macrophages, the protein known as macrophage migration inhibitory factor (MIF) was an enigmatic cytokine for almost 3 decades. In recent years, the discovery of MIF as a product of the anterior pituitary gland and the cloning and expression of bioactive, recombinant MIF protein have led to the definition of its critical biological role in vivo. MIF has the unique property of being released from macrophages and T lymphocytes that have been stimulated by glucocorticoids. Once released, MIF overcomes the inhibitory effects of glucocorticoids on TNFα, IL-1β, IL-6, and IL-8 production by LPS-stimulated monocytes in vitro and suppresses the protective effects of steroids against lethal endotoxemia in vivo. MIF also antagonizes glucocorticoid inhibition of T-cell proliferation in vitro by restoring IL-2 and IFN-γ production. This observation has identified a pivotal role for MIF within the immune system and fills an important gap in our understanding of the control of inflammatory and immune responses. Glucocorticoids have long been considered to be an integral component of the stress response to infection or tissue invasion and serve to modulate inflammatory and immune responses. MIF is the first mediator to be identified that can counter-regulate the inhibitory effects of glucocorticoids and thus plays a critical role in the host control of inflammation and immunity.
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Bozza Marcelo T., Lintomen Leticia, Kitoko Jamil Z., Paiva Cláudia N., Olsen Priscilla C., The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation, Clinical Reviews in Allergy & Immunology, 58, 1, 2020. Crossref
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Gow Debbie J, Jackson Hilary, Forsythe Peter, Gow Adam G, Mellanby Richard J, Hume David A, Nuttall Tim, Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis, Veterinary Dermatology, 30, 2, 2019. Crossref
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Haitjema Saskia, Hoefer Imo E., When the Myocardium Gets MIFfed: Macrophage Inhibitory Factor as a Biomarker in Acute Coronary Artery Disease, Canadian Journal of Cardiology, 35, 10, 2019. Crossref
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Yang Minggen, Xu Zhenqiang, Zhuang Zhiming, Macrophages affect immune inflammation and proliferation in benign prostatic hyperplasia via androgen receptor and CD40/CD40L signaling pathway, Tissue and Cell, 64, 2020. Crossref
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Do Jong Geol, Noh Sun Up, Chae Seoung Wan, Yoon Kyung Jae, Lee Yong-Taek, Excessive walking exercise precipitates diabetic neuropathic foot pain: hind paw suspension treadmill exercise experiment in a rat model, Scientific Reports, 10, 1, 2020. Crossref
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Chen Xi, Chen Yifan, Qi Dake, Cui Donghong, Multifaceted interconnections between macrophage migration inhibitory factor and psychiatric disorders, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 112, 2022. Crossref
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Harjacek Miroslav, Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The “Out of the Box” View on Epigenetics, Neuroendocrine Pathways and Role of the Macrophage Migration Inhibitory Factor (MIF), Frontiers in Medicine, 8, 2021. Crossref
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Varyani Fumi, Löser Stephan, Filbey Kara J., Harcus Yvonne, Drurey Claire, Poveda Marta Campillo, Rasid Orhan, White Madeleine P. J., Smyth Danielle J., Gerbe François, Jay Philippe, Maizels Rick M., The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF), Mucosal Immunology, 2022. Crossref
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Teipel Stefan J., Dyrba Martin, Ballarini Tommaso, Brosseron Frederic, Bruno Davide, Buerger Katharina, Cosma Nicoleta-Carmen, Dechent Peter, Dobisch Laura, Düzel Emrah, Ewers Michael, Fliessbach Klaus, Haynes John D., Janowitz Daniel, Kilimann Ingo, Laske Christoph, Maier Franziska, Metzger Coraline D., Munk Matthias H., Peters Oliver, Pomara Nunzio, Preis Lukas, Priller Josef, Ramírez Alfredo, Roy Nina, Scheffler Klaus, Schneider Anja, Schott Björn H., Spottke Annika, Spruth Eike J., Wagner Michael, Wiltfang Jens, Jessen Frank, Heneka Michael T., Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer’s Disease Spectrum, Journal of Alzheimer's Disease, 85, 3, 2022. Crossref
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Vukićević Dušan, Rovčanin Branislav, Gopčević Kristina, Stanković Sanja, Vučević Danijela, Jorgačević Bojan, Mladenović Dušan, Vesković Milena, Samardžić Janko, Ješić Rada, Radosavljević Tatjana, The Role of MIF in Hepatic Function, Oxidative Stress, and Inflammation in Thioacetamide-induced Liver Injury in Mice: Protective Effects of Betaine, Current Medicinal Chemistry, 28, 16, 2021. Crossref
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Kong Yao-Zhong, Chen Qiyan, Lan Hui-Yao, Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation, International Journal of Molecular Sciences, 23, 9, 2022. Crossref
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Arnold Amanda R., Chassaing Benoit, Pearce Bradley D., Huhman Kim L., Dietary emulsifier consumption alters gene expression in the amygdala and paraventricular nucleus of the hypothalamus in mice, Scientific Reports, 12, 1, 2022. Crossref
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Cho Young-Duck, Choi Sung-Hyuk, Park Sung-Jun, Kim Jung-Youn, Lim Chae-Seung, Yu Woo-Sung, Kyung Hwan Kim, Shin Tae-Gun, The impacts of oxygen and pentoxifylline in hypoxic condition, European Journal of Inflammation, 20, 2022. Crossref
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Lebold Katie M., Drake Matthew G., Pincus Alexandra B., Pierce Aubrey B., Fryer Allison D., Jacoby David B., Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite–exposed Mice, American Journal of Respiratory Cell and Molecular Biology, 67, 1, 2022. Crossref
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Wu Kai-Min, Zhang Ya-Ru, Huang Yu-Yuan, Dong Qiang, Tan Lan, Yu Jin-Tai, The role of the immune system in Alzheimer’s disease, Ageing Research Reviews, 70, 2021. Crossref
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Stošić-Grujičić Stanislava, Saksida Tamara, Miljković Đorđe, Stojanović Ivana, MIF and insulin: Lifetime companions from common genesis to common pathogenesis, Cytokine, 125, 2020. Crossref
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Thapa Komal, Khan Heena, Sharma Uma, Grewal Amarjot Kaur, Singh Thakur Gurjeet, Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases, Life Sciences, 267, 2021. Crossref
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Juárez-Avelar Imelda, Rodríguez Tonathiu, García-García Ana P., Rodríguez-Sosa Miriam, Macrophage migration inhibitory factor (MIF): Its role in the genesis and progression of colorectal cancer, in Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives, 2021. Crossref
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Ding Na, Li Peng-Lei, Wu Kai-Li, Lv Tie-Gang, Yu Wen-Lu, Hao Jian, Macrophage migration inhibitory factor levels are associated with disease activity and possible complications in membranous nephropathy, Scientific Reports, 12, 1, 2022. Crossref