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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i5.20
pages 377-402

Response of γδ T Cells to Plant-Derived Tannins

Jeff Holderness
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718
Jodi F. Hedges
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718
Katie Daughenbaugh
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718
Emily Kimmel
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718
Jill Graff
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718
Brett Freedman
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718
Mark A. Jutila
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718

要約

Many pharmaceutical drugs arc isolated from plants used in traditional medicines, and new plant-derived pharmaceutical drugs continue to be identified. Relevant to this review, different plant-derived agonists for γδ T cells are described that impart effector functions upon distinct subsets of these cells. Recently, plant tannins have been defined as one class of γδ T cell agonist and appear to preferentially activate the mucosal population. Mucosal γδ T cells function to modulate tissue immune responses and induce epithelium repair. Select tannins, isolated from apple peel, rapidly induce immune gene transcription in γδ T cells, leading to cytokinc production and increased responsiveness to secondary signals. Activity of these tannin preparations tracks to the procyanidin fraction, with the procyanidin trimer (C1) having the most robust activity defined to date. The response to the procyanidins is evolutionarily conserved in that responses are seen with human, bovine, and murine γδ T cells, although human cells show less selectivity. Procyanidin-induced responses described in this review likely account for the expansion of mucosal γδ T cells seen in mice and rats fed soluble extracts of tannins. Use of procyanidins to activate γδ T cells may represent a novel approach for the treatment of tissue damage and autoimmune diseases.


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