ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v25.i4.20
pages 263-288

Signaling Pathways Involved in Glucocorticoid-Induced Apoptosis of Thymocytes

Sandrine Lepine
Biomembranes et Messagers Cellulaires, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8619, Universite Paris XI-Orsay, France
Jean-Claude Sulpice
Biomembranes et Messagers Cellulaires, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8619, Universite Paris XI-Orsay, France
Francoise Giraud
Biomembranes et Messagers Cellulaires, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8619, Universite Paris XI-Orsay, France

要約

This review synthesizes recent insights on the signaling pathways triggered by glucocorticoids during apoptosis of thymocytes. Thymocyte apoptosis is a complex process, which is involved in thymic selection. Even if the main partners are identified, there still remain dark zones on the whole pathway and notably on the crosstalk between each signaling cascade. Glucocorticoids trigger thymocyte apoptosis by enhancing cyclin-dependent kinase 2 activity, downregulating the expression of antiapoptotic Bcl-2 proteins, and upregulating that of proapoptotic Bcl-2 proteins. These events result in mitochondrial alterations and subsequent caspase activation. Proteasome intervenes at various levels of the signaling cascades—for instance, degrading the glucocorticoid receptor or caspase inhibitory proteins. Changes in intracellular K+ and Ca2+ concentrations are involved in caspase and endonulease activation. All these effects are dependent on macromolecular synthesis. The only known non-genomic effect of glucocorticoids is an early production of sphingolipids (ceramide and sphingosine), which are involved in caspase activation independent of mitochondrial alterations. Externalization of phosphatidylserine, a process mediating phagocytosis of dying thymocytes, depends on pathways that diverge from those leading to nuclear apoptosis.


Articles with similar content:

Positive and Negative Thymocyte Selection
Critical Reviews™ in Immunology, Vol.18, 1998, issue 4
Takashi Saito , Norihiko Watanabe
Accelerated Proteasomal Activity Induced by Pb2+, Ga3+, or Cu2+ Exposure Does Not Induce Degradation of αt-Synuclein
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 1
Nurit Grunberg-Etkovitz, Almog Avital, Daniel Offen, Zvi Malik, Nirit Lev, Debby Ickowicz
Maintenance and Attrition of T-Cell Memory
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Lakshmi Krishnan, Subash Sad
Toll-like Receptor 2 and 4 in Cancer Immunotherapy: Is Nitric Oxide a Mediator?
Forum on Immunopathological Diseases and Therapeutics, Vol.1, 2010, issue 4
Catherine Paul, Ali Bettaieb, Jean-Francois Jeannin, Cedric Seignez, Amandine Martin
Role of NF-κB in Tumorigenesis
Forum on Immunopathological Diseases and Therapeutics, Vol.4, 2013, issue 2
Gautam Sethi, Muthu K. Shanmugam, Alan P. Kumar, Benny K. H. Tan