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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Regulatory T Cells for Tolerance Therapy: Revisiting the Concept

巻 31, 発行 3, 2011, pp. 189-207
DOI: 10.1615/CritRevImmunol.v31.i3.20
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Christian LeGuern
Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital East, Harvard Medical School, Boston, MA, USA

要約

The discovery of regulatory T cells (Tregs) as a crucial component of peripheral down-regulation of immunity to self and allogeneic antigens has raised legitimate hope for the development of Treg-based clinical protocols for tolerance to allografts. The present review addresses the question of whether therapeutic Tregs are ready to enter the clinical transplantation arena. In light of recent experimental observations, we will revisit some fundamentals of T cell and Treg biology that stress the need for further studies prior to applications and provide conceptual cues for novel therapeutic approaches.

キーワード: immune regulation, tolerance, cell therapy, Treg, thymus, deletion, suppression
によって引用された

  1. Handzlik Michal K., Shaw Andrew J., Dungey Maurice, Bishop Nicolette C., Gleeson Michael, The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells, European Journal of Applied Physiology, 113, 7, 2013. Crossref

  2. Camirand Geoffrey, Wang Ying, Lu Yuning, Wan Yisong Y., Lin Yan, Deng Songyan, Guz Galip, Perkins David L., Finn Patricia W., Farber Donna L., Flavell Richard A., Shlomchik Warren D., Lakkis Fadi G., Rudd Christopher E., Rothstein David M., CD45 ligation expands Tregs by promoting interactions with DCs, Journal of Clinical Investigation, 124, 10, 2014. Crossref

  3. Fung Man C., Bowen Debra L., Cell-Based Biologic Therapy for the Treatment of Medical Diseases, in Therapeutic Delivery Solutions, 2014. Crossref

  4. Choi Inseon S., Immune Tolerance by Induced Regulatory T Cells in Asthma, Allergy, Asthma & Immunology Research, 4, 3, 2012. Crossref

  5. Nagato Kaoru, Spear Timothy T., Nishimura Michael I., Influence of Antigen Receptor Avidity, Affinity, and Specificity on Genetically Engineered T Cells, in Developments in T Cell Based Cancer Immunotherapies, 2015. Crossref

  6. Salcido-Ochoa Francisco, Yusof Nurhashikin, Hue Susan Swee-Shan, Haase Doreen, Kee Terence, Rotzschke Olaf, Are We Ready for the Use of Foxp3+Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation?, Journal of Transplantation, 2012, 2012. Crossref

  7. Di Caro Valentina, Phillips Brett, Engman Carl, Harnaha Jo, Trucco Massimo, Giannoukakis Nick, Fiorina Paolo, Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice, PLoS ONE, 9, 1, 2014. Crossref

  8. Duran-Struuck Raimon, Matar Abraham J., Crepeau Rebecca L., Teague Alexander G.S., Horner Benjamin M., Pathiraja Vimukthi, Spitzer Thomas R., Fishman Jay A., Bronson Roderick T., Sachs David H., Huang Christene A., Donor Lymphocyte Infusion–Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation, Biology of Blood and Marrow Transplantation, 22, 11, 2016. Crossref

  9. Wu Yi-Ying, Hsieh Chin-Tung, Tsay Gregory J., Kao Jung-Ta, Chiu Ying-Ming, Shieh Dong-Chen, Lee Yi-Ju, Recruitment of CCR6+  Foxp3+ regulatory gastric infiltrating lymphocytes in Helicobacter pylori gastritis, Helicobacter, 24, 1, 2019. Crossref

  10. Bézie Séverine, Picarda Elodie, Ossart Jason, Martinet Bernard, Anegon Ignacio, Guillonneau Carole, Compensatory Regulatory Networks between CD8 T, B, and Myeloid Cells in Organ Transplantation Tolerance, The Journal of Immunology, 195, 12, 2015. Crossref

  11. Zaini Rana G., Al-Rehaili Amani A., The Therapeutic Strategies of Regulatory T Cells in Malignancies and Stem Cell Transplantations, Journal of Oncology, 2019, 2019. Crossref

  12. Weiss M. L., López Yelica, McIntosh K. R., Wharton’s Jelly-Derived Mesenchymal Stromal Cells as Immunoregulatory Cells, in Human Fetal Tissue Transplantation, 2013. Crossref

  13. Rossetti Maura, Spreafico Roberto, Saidin Suzan, Chua Camillus, Moshref Maryam, Leong Jing Yao, Tan York Kiat, Thumboo Julian, van Loosdregt Jorg, Albani Salvatore, Ex Vivo–Expanded but Not In Vitro–Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell–Specific Demethylated Region, The Journal of Immunology, 194, 1, 2015. Crossref

  14. Lee Seok-Joo, Kim Hyun-Je, Byun Na-ri, Park Chung-Gyu, Donor-Specific Regulatory T Cell-Mediated Immune Tolerance in an Intrahepatic Murine Allogeneic Islet Transplantation Model with Short-Term Anti-CD154 mAb Single Treatment, Cell Transplantation, 29, 2020. Crossref

  15. Giannoukakis Nick, Trucco Massimo, A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus, Current Opinion in Endocrinology, Diabetes & Obesity, 19, 4, 2012. Crossref

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