年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
Interleukin-33 and its Receptor in Pulmonary Inflammatory Diseases
要約
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It modulates immune responses and biological functions through binding to its membrane receptor, ST2L. ST2L is a member of the Toll-like/IL-1 (TIR)-receptor superfamily, and its isoform, soluble ST2 (sST2), functions as an inhibitor of the IL-33/ST2L pathway. Levels of IL-33 and sST2 in serum and bronchoalveolar lavage fluid (BAL) are known biomarkers for a variety of disorders such as heart failure, non-small-cell lung cancer, and pulmonary inflammatory diseases. IL-33 also exists in the nuclei, and nuclear IL-33 seems to regulate cytokine gene expression. In this review, we focus on the role of IL-33/ST2 in the pathogenesis of pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), and lung injury.
-
Liu Jie, Wang Wang, Wang Lei, Chen Shihao, Tian Bo, Huang Kewu, Corrigan Chris J., Ying Sun, Wang Wei, Wang Chen, IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells, EBioMedicine, 33, 2018. Crossref
-
Kumar Rahul, Graham Brian, IL-33-HIF1α Axis in Hypoxic Pulmonary Hypertension, EBioMedicine, 33, 2018. Crossref
-
Ravichandran Kameswaran, Holditch Sara, Brown Carolyn N., Wang Qian, Ozkok Abdullah, Weiser-Evans Mary C., Nemenoff Raphael, Miyazaki Makoto, Thiessen-Philbrook Heather, Parikh Chirag R., Ljubanovic Danica, Edelstein Charles L., IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer, American Journal of Physiology-Renal Physiology, 314, 3, 2018. Crossref
-
Doyle Alfred D., Mukherjee Manali, LeSuer William E., Bittner Tyler B., Pasha Saif M., Frere Justin J., Neely Joseph L., Kloeber Jake A., Shim Kelly P., Ochkur Sergei I., Ho Terence, Svenningsen Sarah, Wright Benjamin L., Rank Matthew A., Lee James J., Nair Parameswaran, Jacobsen Elizabeth A., Eosinophil-derived IL-13 promotes emphysema, European Respiratory Journal, 53, 5, 2019. Crossref
-
Kotsiou Ourania S., Jagirdar Rajesh M., Papazoglou Eleftherios D., Hatzoglou Chrissi, Gourgoulianis Konstantinos I., Zarogiannis Sotirios G., Pleural Effusion IL-33/sST2 Levels and Effects of Low and High IL-33/sST2 Levels on Human Mesothelial Cell Adhesion and Migration, Inflammation, 42, 6, 2019. Crossref
-
Sage Michaël, See Wendy, Nault Stéphanie, Morin Christophe, Michalski Christina, Chabot Benoit, Marouan Sofia, Lavoie Pascal M., Micheau Philippe, Praud Jean-Paul, Fortin-Pellerin Étienne, Effect of Low Versus High Tidal-Volume Total Liquid Ventilation on Pulmonary Inflammation, Frontiers in Physiology, 11, 2020. Crossref
-
Mamber Stephen W., Gurel Volkan, Lins Jeremy, Ferri Fred, Beseme Sarah, McMichael John, Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD), Journal of Cannabis Research, 2, 1, 2020. Crossref
-
Berman Reena, Kopf Katrina W., Min Elysia, Huang Jie, Downey Gregory P., Alam Rafeul, Chu Hong Wei, Day Brian J., IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice, Toxicology and Applied Pharmacology, 404, 2020. Crossref
-
Aarstad Helene Hersvik, Moe Svein Erik Emblem, Bruserud Øystein, Lybak Stein, Aarstad Hans Jørgen, Tvedt Tor Henrik Anderson, The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles, Biomedicines, 8, 10, 2020. Crossref
-
Aarstad Helene Hersvik, Guðbrandsdottir Gigja, Hjelle Karin M., Bostad Leif, Bruserud Øystein, Tvedt Tor Henrik Anderson, Beisland Christian, The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile, Cancers, 12, 7, 2020. Crossref
-
de la Rica Roberto, Borges Marcio, Gonzalez-Freire Marta, COVID-19: In the Eye of the Cytokine Storm, Frontiers in Immunology, 11, 2020. Crossref
-
Berman Reena, Rose Cecile S., Downey Gregory P., Day Brian J., Chu Hong Wei, Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease, Chemical Research in Toxicology, 34, 12, 2021. Crossref
-
Rozario Christoforos, Martínez-Sobrido Luis, McSorley Henry J., Chauché Caroline, Could Interleukin-33 (IL-33) Govern the Outcome of an Equine Influenza Virus Infection? Learning from Other Species, Viruses, 13, 12, 2021. Crossref
-
Piyadasa Hadeesha, Lloyd Dylan, Lee Amy H.Y., Altieri Anthony, Hemshekhar Mahadevappa, Osawa Natasha, Basu Sujata, Blimkie Travis, Falsafi Reza, Halayko Andrew J., Hancock Robert E.W., Mookherjee Neeloffer, Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1866, 12, 2020. Crossref
-
Ragusa Rosetta, Basta Giuseppina, Del Turco Serena, Caselli Chiara, A possible role for ST2 as prognostic biomarker for COVID-19, Vascular Pharmacology, 138, 2021. Crossref
-
Vu Luan D., Saravia Jordy, Jaligama Sridhar, Baboeram Panday Rajshri V., Sullivan Ryan D., Mancarella Salvatore, Cormier Stephania A., Kimura Dai, Deficiency in ST2 signaling ameliorates RSV-associated pulmonary hypertension, American Journal of Physiology-Heart and Circulatory Physiology, 321, 2, 2021. Crossref
-
Dukhinova Marina, Kokinos Elena, Kuchur Polina, Komissarov Alexey, Shtro Anna, Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics, Cytokine & Growth Factor Reviews, 59, 2021. Crossref
-
Alladina Jehan, Levy Sean D., Cho Josalyn L., Brait Kelsey L., Rao Sowmya R., Camacho Alexander, Hibbert Kathryn A., Harris R. Scott, Medoff Benjamin D., Januzzi James L., Thompson B. Taylor, Bajwa Ednan K., Plasma Soluble Suppression of Tumorigenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure, American Journal of Respiratory and Critical Care Medicine, 203, 10, 2021. Crossref
-
Shekhar Shashank, Yadav Amit K., Khosla Ajit, Solanki Pratima R., Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection, ECS Sensors Plus, 1, 4, 2022. Crossref