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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Effect of Age on the Immunoglobulin Class Switch

巻 24, 発行 5, 2004, 24 pages
DOI: 10.1615/CritRevImmunol.v24.i5.10
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要約

Aging represents a complex remodelling in which both specific and innate immunity deteriorate. Age-related changes in humoral immunity involve reduced vaccine responses and increased production of auto-antibodies. Although T-cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. In this review, we provide an overview of age-related changes in B-cell functions and markers, including transcription factors, and also discuss controversies in the field of B-cell aging. We summarize our recent results, showing that splenic B cells from senescent mice are deficient in production of secondary isotypes (IgG1, IgG2a, IgG3, IgE), class switch recombination (CSR), and expression of the transcription factor E47. We also demonstrate that there is more Id2 (a negative regulator of E47) in old activated B cells. E47 is required for CSR, at least in part, via expression of activation-induced cytidine deaminase (AID). Our studies show that impaired induction of E47, and, subsequently, AID, contribute to poor CSR and production of secondary isotypes in senescence. We also present new data indicating the absence of DNA switch region excision circles for CSR in old activated B cells, confirming the location of the defect at the DNA endonucleolytic step. And, finally, we show that there is no change in NF-κB or Blimp-1 in old vs young stimulated B cells.

によって引用された
  1. Riley Richard L., Blomberg Bonnie B., Frasca Daniela, B cells, E2A, and aging, Immunological Reviews, 205, 1, 2005. Crossref

  2. Gorczynski Reginald M., Terzioglu Ender, Aging and the immune system, International Urology and Nephrology, 40, 4, 2008. Crossref

  3. Ademokun Alexander, Wu Yu-Chang, Dunn-Walters Deborah, The ageing B cell population: Composition and function, Biogerontology, 11, 2, 2010. Crossref

  4. Nagaoka H., Tran T. H., Kobayashi M., Aida M., Honjo T., Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity, International Immunology, 22, 4, 2010. Crossref

  5. Frasca Daniela, Riley Richard L., Blomberg Bonnie B., Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans, Seminars in Immunology, 17, 5, 2005. Crossref

  6. Suzuki Yuhko, Nakamura Takeshi, Tokoro Masaharu, Togano Tomiteru, Ohsaka Manabu, Kohri Mika, Hirata Yasuyoshi, Miyazaki Koji, Danbara Mikio, Horie Ryouichi, Miura Ikuo, Sunakawa Keisuke, Higashihara Masaaki, A case of giardiasis expressing severe systemic symptoms and marked hypereosinophilia, Parasitology International, 59, 3, 2010. Crossref

  7. Bakos Noemi, Schöll Isabella, Szalai Krisztina, Kundi Michael, Untersmayr Eva, Jensen-Jarolim Erika, Risk assessment in elderly for sensitization to food and respiratory allergens, Immunology Letters, 107, 1, 2006. Crossref

  8. Buffa Silvio, Bulati Matteo, Pellicanò Mariavaleria, Dunn-Walters Deborah K., Wu Yu-Chang, Candore Giuseppina, Vitello Salvatore, Caruso Calogero, Colonna-Romano Giuseppina, B cell immunosenescence: different features of naive and memory B cells in elderly, Biogerontology, 12, 5, 2011. Crossref

  9. Abedin Sameem, Michel Joshua J., Lemster Bonnie, Vallejo Abbe N., Diversity of NKR expression in aging T cells and in T cells of the aged: The new frontier into the exploration of protective immunity in the elderly, Experimental Gerontology, 40, 7, 2005. Crossref

  10. Sadighi Akha Amir A, Miller Richard A, Signal transduction in the aging immune system, Current Opinion in Immunology, 17, 5, 2005. Crossref

  11. Hao Yi, O'Neill Patrick, Naradikian Martin S., Scholz Jean L., Cancro Michael P., A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice, Blood, 118, 5, 2011. Crossref

  12. Nikolich-Žugich Janko, Messaoudi Ilhem, Mice and flies and monkeys too: Caloric restriction rejuvenates the aging immune system of non-human primates, Experimental Gerontology, 40, 11, 2005. Crossref

  13. Hui George, Hashimoto Caryn, Interleukin-6 has differential influence on the ability of adjuvant formulations to potentiate antibody reponses to a Plasmodium falciparum blood-stage vaccine, Vaccine, 25, 36, 2007. Crossref

  14. Parmentier Henk K., Harms Elmer, Lammers Aart, Nieuwland Mike G.B., Age and genetic selection affect auto-immune profiles of chickens, Developmental & Comparative Immunology, 47, 2, 2014. Crossref

  15. Namkoong Ho, Ishii Makoto, Funatsu Yohei, Kimizuka Yoshifumi, Yagi Kazuma, Asami Takahiro, Asakura Takanori, Suzuki Shoji, Kamo Testuro, Fujiwara Hiroshi, Tasaka Sadatomo, Betsuyaku Tomoko, Hasegawa Naoki, Theory and strategy for Pneumococcal vaccines in the elderly, Human Vaccines & Immunotherapeutics, 12, 2, 2016. Crossref

  16. Chen Una, Lymphoid Cells, in Principles of Tissue Engineering, 2007. Crossref

  17. Naradikian Martin S., Hao Yi, Cancro Michael P., Age-associated B cells: key mediators of both protective and autoreactive humoral responses, Immunological Reviews, 269, 1, 2016. Crossref

  18. de Jong Britt G., Lammers Aart, Oberendorf Leonora A. A., Nieuwland Mike G. B., Savelkoul Huub F. J., Parmentier Henk K., Kaltenboeck Bernhard, Genetic and Phenotypic Selection Affect Natural (Auto-) Antibody Reactivity of Chickens, PLoS ONE, 8, 9, 2013. Crossref

  19. Gubbels Bupp Melanie R., Potluri Tanvi, Fink Ashley L., Klein Sabra L., The Confluence of Sex Hormones and Aging on Immunity, Frontiers in Immunology, 9, 2018. Crossref

  20. Scholz Jean L., Hao Yi, Quinn William J., Cancro Michael P., B Cell Repertoire Changes in Mouse Models of Aging, in Handbook of Immunosenescence, 2018. Crossref

  21. Sugimura Tetsu, Jounai Kenta, Ohshio Konomi, Suzuki Hiroaki, Kirisako Takayoshi, Sugihara Yoshihiko, Fujiwara Daisuke, Long-term administration of pDC-Stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice, International Immunopharmacology, 58, 2018. Crossref

  22. Scholz Jean L., Hao Yi, Quinn William J., Cancro Michael P., B Cell Repertoire Changes in Mouse Models of Aging, in Handbook of Immunosenescence, 2019. Crossref

  23. Scholz Jean L., Quinn William J., Cancro Michael P., B-Cell Repertoire Changes in Mouse Models of Aging, in Handbook on Immunosenescence, 2009. Crossref

  24. Frasca Daniela, Riley Richard L., Blomberg Bonnie B., Transcription Factors in Mature B-Cells During Aging, in Handbook on Immunosenescence, 2009. Crossref

  25. Frasca Daniela, Landin Ana Marie, Riley Richard L., Blomberg Bonnie B., Mechanisms for Decreased Function of B Cells in Aged Mice and Humans, The Journal of Immunology, 180, 5, 2008. Crossref

  26. Slean Meghan M., Panigrahi Gagan B., Ranum Laura P., Pearson Christopher E., Mutagenic roles of DNA “repair” proteins in antibody diversity and disease-associated trinucleotide repeat instability, DNA Repair, 7, 7, 2008. Crossref

  27. Frasca Daniela, Landin Ana Marie, Lechner Suzanne C., Ryan John G., Schwartz Robert, Riley Richard L., Blomberg Bonnie B., Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells, The Journal of Immunology, 180, 8, 2008. Crossref

  28. Frasca Daniela, Van der Put Elaine, Landin Ana Marie, Gong Dapeng, Riley Richard L., Blomberg Bonnie B., RNA Stability of the E2A-Encoded Transcription Factor E47 Is Lower in Splenic Activated B Cells from Aged Mice, The Journal of Immunology, 175, 10, 2005. Crossref

  29. Morita Yuji, Jounai Kenta, Sakamoto Akihiko, Tomita Yasuyuki, Sugihara Yoshihiko, Suzuki Hiroaki, Ohshio Konomi, Otake Masato, Fujiwara Daisuke, Kanauchi Osamu, Maruyama Mitsuo, Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice, Aging, 10, 10, 2018. Crossref

  30. Federoff Howard J., Bowers William J., Immune Shaping and the Development of Alzheimer's Disease Vaccines, Science of Aging Knowledge Environment, 2005, 46, 2005. Crossref

  31. Untersmayr Eva, Diesner Susanne C., Brämswig Kira H., Knittelfelder Regina, Bakos Noemi, Gundacker Claudia, Lukschal Anna, Wallmann Julia, Szalai Krisztina, Pali-Schöll Isabella, Boltz-Nitulescu George, Scheiner Otto, Duschl Albert, Jensen-Jarolim Erika, Characterization of intrinsic and extrinsic risk factors for celery allergy in immunosenescence, Mechanisms of Ageing and Development, 129, 3, 2008. Crossref

  32. Martorana Adriana, Balistreri Carmela Rita, Bulati Matteo, Buffa Silvio, Azzarello Delia Maria, Camarda Cecilia, Monastero Roberto, Caruso Calogero, Colonna-Romano Giuseppina, Double negative (CD19+IgG+IgD−CD27−) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients, Immunology Letters, 162, 1, 2014. Crossref

  33. Fujiki Tsukasa, Matsumoto Shin-Ei, Kishihara Kenji, Katakura Yoshinori, Age-related functional decline of human B cells, Cytotechnology, 74, 2, 2022. Crossref

  34. Bulati Matteo, Buffa Silvio, Martorana Adriana, Candore Giuseppina, Lio Domenico, Caruso Calogero, Colonna-Romano Giuseppina, Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly, Experimental Gerontology, 54, 2014. Crossref

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