ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v26.i3.20
pages 213-230

Is the CD200/CD200 Receptor Interaction More Than Just a Myeloid Cell Inhibitory Signal?

Konstantinos Minas
Department of Ophthalmology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK AB25 2ZD
Janet Liversidge
Department of Ophthalmology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK AB25 2ZD

要約

The membrane glycoprotein CD200, which has a widespread but defined distribution and a structurally similar receptor (CD200R) that transmits an inhibitory signal to cells of the hematopoetic lineage, especially myeloid cells, has been characterized. CD200R expression is restricted predominantly to cells of the myeloid lineage indicating that this ligand/receptor pair has a specific role in controlling myeloid cell function. In addition to CD200R, several related genes have been identified. Whether these gene products also regulate immune function is controversial. CD200R is also expressed by certain subsets of T cells and CD200 may be expressed by antigen-presenting cells, adding additional layers of complexity to the CD200/CD200R axis. Because monocytic myeloid cells provide a link between the innate and adaptive immune response, mechanisms to control their function through receptors such as CD200R will have therapeutic potential. Regulation of immune responses is accomplished by the concerted, but opposing, activity of kinases and phosphatases, fine control often being achieved through paired receptors. In this review, we will consider whether CD200R signaling functions within a framework of paired activating and inhibitory receptors and whether the inhibitory signal delivered has functional consequences beyond inhibition of myeloid cell proinflammatory activation.


Articles with similar content:

Tuning the Rheostat of the Myelopoietic System via Fas and TRAIL
Critical Reviews™ in Immunology, Vol.23, 2003, issue 4
Inge Tinhofer, Gabriele Anether, Richard Greil, Karin Johrer
Expression and Function of Recombination Activating Genes in Mature В Cells
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
Masaki Hikida, Hitoshi Ohmori
CD28/B7 Costimulation: A Review
Critical Reviews™ in Immunology, Vol.18, 1998, issue 5
Khuong A. Nguyen, Vijay K. Kuchroo, Edward A. Greenfield
Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
Critical Reviews™ in Immunology, Vol.34, 2014, issue 6
Beena Jeevan-Raj , Camille Grandclement, Werner Held, Elisenda Alari-Pahissa
Crossregulation Between Th1 and Th2 Cells
Critical Reviews™ in Immunology, Vol.18, 1998, issue 4
Timothy B. Oriss, Penelope A. Morel