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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v31.i4.10
pages 265-295

PD-1 and Autoimmunity

Shimpei Kasagi
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Seiji Kawano
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Shunichi Kumagai
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

要約

An initiating T cell response requires both costimulatory signaling and T cell receptor/MHC binding. The immune system balances positive and negative costimulatory signal pathways to activate and deactivate T cells. This review focuses primarily on PD-1 and its ligands, which form a crucial inhibitory costimulatory pathway for maintaining peripheral tolerance, and their contribution to autoimmunity. Since 1992, when PD-1 was isolated, many studies have described the physiological roles of PD-1 signaling, reported relationships between Pdcd-1 gene polymorphism and autoimmune diseases, and applied PD-1/PD-1 ligand modulation to clinical trials. This review summarizes recent advances and future therapeutic applications of PD-1 and its ligands to autoimmune diseases.

キーワード: PD-1, PD-L, autoimmunity

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