ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i6.20
pages 503-524

The Structure and Function of γс-Dependent Cytokines and Receptors: Regulation of T Lymphocyte Development and Homeostasis

You-Wen He
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136.
Thomas R. Malek
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136.

要約

Five cytokines, IL-2, IL-4, IL-7, IL-9, and IL-15, form one group that is characterized by utilizing the common γ chain (γc) as a receptor subunit. Examination of the phenotype of various cytokine or cytokine receptor "knockout" mice demonstrates that these cytokines are critical for normal lymphocyte development and subsequent functional activity of the peripheral immune compartment. This review summarizes the structural and functional properties of each of these five cytokines and their receptors, including the known redundant pathways for each cytokine or receptor. The contribution of these cytokines and receptors will then be considered in detail with respect to regulation of T lymphocyte development and homeostasis of the peripheral T cell compartment.


Articles with similar content:

Role of SLAM Family Receptors and Specific Adapter SAP in Innate-Like Lymphocytes
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
Jordi Sintes, Xavier Romero, Pablo Engel
Role of IL-21 and IL-21 Receptor on B Cells in HIV Infection
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Suresh Pallikkuth, Savita Pahwa, Anita Parmigiani
The Role of Cyclin-Dependent Kinases in T-Cell Development, Proliferation, and Function
Critical Reviews™ in Immunology, Vol.26, 2006, issue 3
Emily A. Rowell, Andrew D. Wells
Mechanisms of Lipid Antigen Presentation by CD1
Critical Reviews™ in Immunology, Vol.19, 1999, issue 1
Robin M. Jackman, Steven A. Porcelli
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways
Critical Reviews™ in Immunology, Vol.38, 2018, issue 4
Taro Kawai, Noor Hasima Nagoor, Sophia P. M. Sok, Daisuke Ori