年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
Toll-like Receptor Modulation in Head and Neck Cancer
要約
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors that have emerged as key mediators of immune functions. Activation of TLRs is a first line of defense of the immune system, leading to the activation and recruitment of different types of immune cells to sites of infection and malignant cell growth. Cells of human cancers, such as head and neck squamous cell carcinoma (HNSCC), are known to develop numerous molecular strategies to escape from efficient antitumor immune responses. It is supposed that tumor production of various immunosuppressive mediators contributes to impaired and altered immune functions in cancer patients. The molecular mechanisms responsible for these immunomodulatory processes and the biosynthesis of the immunosuppressive HNSCC microenvironment remain mostly unknown. Recently, different studies have shown that tumor cells are able to modulate the expression and function of TLR proteins in different kinds of immune cells. In this review, we present recent progress in these studies on the modulation of TLR expression and signaling through malignant head and neck cancer.
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Starska K, Forma E, Bryś M, Głowacka E, Lewy-Trenda I, Łukomski M, Krajewska WM, The expression of TLR pathway molecules in peripheral blood mononuclear cells and their relationship with tumor invasion and cytokine secretion in laryngeal carcinoma, Advances in Medical Sciences, 57, 1, 2012. Crossref
-
Meyer Christian, Pries Ralph, Wollenberg Barbara, Established and novel NF-κB inhibitors lead to downregulation of TLR3 and the proliferation and cytokine secretion in HNSCC, Oral Oncology, 47, 9, 2011. Crossref
-
Ruan Min, Zhang Zun, Li Siyi, Yang Wenjun, Wang Lizheng, Zhang Chenping, Increased expression of Toll-like receptor-9 has close relation with tumour cell proliferation in oral squamous cell carcinoma, Archives of Oral Biology, 56, 9, 2011. Crossref
-
Rich Alison Mary, Hussaini Haizal Mohd, Parachuru Venkata P. B., Seymour Gregory J., Toll-Like Receptors and Cancer, Particularly Oral Squamous Cell Carcinoma, Frontiers in Immunology, 5, 2014. Crossref
-
Wulff Sandra, Pries Ralph, Wollenberg Barbara, Cytokine release of human NK cells solely triggered with Poly I:C, Cellular Immunology, 263, 2, 2010. Crossref
-
Echarri María, Lopez-Martin Ana, Hitt Ricardo, Targeted Therapy in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (LA-R/M HNSCC), Cancers, 8, 3, 2016. Crossref
-
Duray Anaëlle, Demoulin Stéphanie, Hubert Pascale, Delvenne Philippe, Saussez Sven, Immune Suppression in Head and Neck Cancers: A Review, Clinical and Developmental Immunology, 2010, 2010. Crossref
-
Tsuchiya Masa, Piras Vincent, Choi Sangdun, Akira Shizuo, Tomita Masaru, Giuliani Alessandro, Selvarajoo Kumar, Sommer Peter, Emergent Genome-Wide Control in Wildtype and Genetically Mutated Lipopolysaccarides-Stimulated Macrophages, PLoS ONE, 4, 3, 2009. Crossref
-
Klein Johanna C., Wild Clarissa A., Lang Stephan, Brandau Sven, Differential immunomodulatory activity of tumor cell death induced by cancer therapeutic toll-like receptor ligands, Cancer Immunology, Immunotherapy, 65, 6, 2016. Crossref
-
Fu Qiu , Maniar Amudhan, Quevedo Diaz Marco, Chapoval Andrei I, Medvedev Andrei E, Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors, Innate Immunity, 17, 4, 2011. Crossref
-
Langevin Scott, Kuhnell Damaris, Parry Tess, Biesiada Jacek, Huang Shouxiong, Wise-Draper Trisha, Casper Keith, Zhang Xiang, Medvedovic Mario, Kasper Susan, Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cellsin vitroreveals common secretion profiles and potential utility as salivary biomarkers, Oncotarget, 8, 47, 2017. Crossref
-
López-Ozuna Vanessa M., Gupta Ishita, Kiow Ryan Liu Chen, Matanes Emad, Kheraldine Hadeel, Yasmeen Amber, Khalil Ashraf, Vranic Semir, Al Moustafa Ala-Eddin, Farsi Halema F Al, Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis, Toxics, 8, 3, 2020. Crossref
-
Moreira Dayson, Sampath Sagus, Won Haejung, White Seok Voon, Su Yu-Lin, Alcantara Marice, Wang Chongkai, Lee Peter, Maghami Ellie, Massarelli Erminia, Kortylewski Marcin, Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity, Journal of Clinical Investigation, 131, 2, 2021. Crossref