ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2015015495
pages 293-323

The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation

Patricia E. Collins
Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Ruaidhri J. Carmody
Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

要約

Endotoxin tolerance in macrophages is a key regulatory mechanism to limit the innate immune response to infection or injury. Long considered a state of unresponsiveness to Toll-like receptor activation, tolerance is now recognized as a state of altered responsiveness to infection or injury. Endotoxin tolerance leads to a shift away from a pro-inflammatory response toward a response with key anti-inflammatory and pro-resolution features. Advances in our understanding of Toll-like receptor function have identified a number of molecular mechanisms that promote tolerance, but how these are integrated to achieve gene-specific regulation is an important outstanding question. The potential to harness the mechanisms of endotoxin tolerance to promote the resolution of chronic inflammation warrants the continued investigation of this fundamental feature of innate immunity. This review focuses on the endotoxin tolerant state, our understanding of the underlying molecular mechanisms, and the clinical significance of endotoxin tolerance.


Articles with similar content:

Interleukin 35−Producing B Cells (i35-Breg): A New Mediator of Regulatory B-Cell Functions in CNS Autoimmune Diseases
Critical Reviews™ in Immunology, Vol.35, 2015, issue 1
Charles E. Egwuagu, Cheng-Rong Yu
Strategies to enhance NK cell function for the treatment of tumors and infections
Critical Reviews™ in Immunology, Vol.38, 2018, issue 2
Taku Kambayashi, Jacquelyn Freund-Brown, Leilani Chirino
The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Veronica M. Ringel-Scaia, Irving C. Allen, Dylan K. McDaniel
Toll-Like Receptor Family in Domestic Animal Species
Critical Reviews™ in Immunology, Vol.28, 2008, issue 6
Federica Riva, Lauretta Turin
Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm
Critical Reviews™ in Immunology, Vol.28, 2008, issue 4
Sharlene Velichko, Reen Wu, Philip Thai, Li-Yin Hung, Fei Huang