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Critical Reviews™ in Immunology
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ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2015014510
pages 203-251

MHC Genes Linked to Autoimmune Disease

Philip Deitiker
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas
M. Zouhair Atassi
Baylor College of Medicine Houston, TX 77030

要約

Autoimmune diseases (ADs), or autoinflammatoiy diseases, are growing in complexity as diagnoses improve and many factors escalate disease risk. Considerable genetic similarity is found among ADs, and they are frequently associated with major histocompatibility complex (MHC) genes. However, a given disease may be associated with more than one human leukocyte antigen (HLA) allotype, and a given HLA may be associated with more than one AD. The associations of non-MHC genes with AD present an additional problem, and the situation is further complicated by the role that other factors, such as age, diet, therapeutic drugs, and regional influences, play in disease. This review discusses some of the genetics and biochemistry of HLA-linked AD and inflammation, covering some of the best-studied examples and summarizing indicators for class I− and II−mediated disease. However, the scope of this review limits a detailed discussion of all known ADs.


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