年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
The Inflammasome and Its Regulation
要約
Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response to a number of exogenous and endogenous danger signals, leading to the production of pro-inflammatory cytokines and induction of inflammatory cell death through the activation of caspase-1. Inflammasomes have been implicated in a wide range of physiological and pathological processes, including host defense against microbial pathogens, maintenance of intestinal homeostasis, and even development of inflammatory disorders. Thus, inflammasomes can be both beneficial and detrimental, and understanding the mechanisms involved in inflammasome activation may provide a better approach to prevent the harmful effects of the inflammatory response. Although inflammasome complexes are formed via protein-protein interactions between their components, accumulating evidence suggests that inflammasome activation is positively and negatively regulated by ligand-binding receptors, accessory proteins, other caspases, cytokines, kinases/phosphatases, redox sensors, ion homeostasis, second messengers, organelles, cytoskeleton, and autophagy, among others. Moreover, inflammasome activation can result in the formation of another caspase-1-activating protein complex, the ASC speck/pyroptosome, which is also tightly controlled. In this review, we discuss how the assembly of inflammasomes and ASC speck is regulated by complex mechanisms. Recent findings on effector functions and biological roles of inflammasomes also are summarized.
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Doyle Timothy M., Chen Zhoumou, Durante Mariaconcetta, Salvemini Daniela, Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway, The Journal of Pain, 20, 8, 2019. Crossref
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Zimmermann Arthur, Necrobiology of Liver Cancer: Autophagy and Cellular Senescence, in Tumors and Tumor-Like Lesions of the Hepatobiliary Tract, 2016. Crossref
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Xu Dongyi, Wu Xingping, Peng Lianci, Chen Tingting, Huang Qingyuan, Wang Yu, Ye Chao, Peng Yuanyi, Hu Dongliang, Fang Rendong, The Critical Role of NLRP6 Inflammasome in Streptococcus pneumoniae Infection In Vitro and In Vivo, International Journal of Molecular Sciences, 22, 8, 2021. Crossref
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Zou Xin-Sen, Xie Lu, Wang Wen-Yan, Zhao Gao-Yang, Tian Xin-Yue, Chen Meng-Hua, Pomelo peel oil alleviates cerebral NLRP3 inflammasome activation in a cardiopulmonary resuscitation rat model, Experimental and Therapeutic Medicine, 21, 3, 2021. Crossref
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