ライブラリ登録: Guest
Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

The Inflammasome and Its Regulation

巻 34, 発行 1, 2014, pp. 41-80
DOI: 10.1615/CritRevImmunol.2013008686
Get accessGet access

要約

Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response to a number of exogenous and endogenous danger signals, leading to the production of pro-inflammatory cytokines and induction of inflammatory cell death through the activation of caspase-1. Inflammasomes have been implicated in a wide range of physiological and pathological processes, including host defense against microbial pathogens, maintenance of intestinal homeostasis, and even development of inflammatory disorders. Thus, inflammasomes can be both beneficial and detrimental, and understanding the mechanisms involved in inflammasome activation may provide a better approach to prevent the harmful effects of the inflammatory response. Although inflammasome complexes are formed via protein-protein interactions between their components, accumulating evidence suggests that inflammasome activation is positively and negatively regulated by ligand-binding receptors, accessory proteins, other caspases, cytokines, kinases/phosphatases, redox sensors, ion homeostasis, second messengers, organelles, cytoskeleton, and autophagy, among others. Moreover, inflammasome activation can result in the formation of another caspase-1-activating protein complex, the ASC speck/pyroptosome, which is also tightly controlled. In this review, we discuss how the assembly of inflammasomes and ASC speck is regulated by complex mechanisms. Recent findings on effector functions and biological roles of inflammasomes also are summarized.

によって引用された
  1. Mohamed Islam N., Ishrat Tauheed, Fagan Susan C., El-Remessy Azza B., Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit, Antioxidants & Redox Signaling, 22, 13, 2015. Crossref

  2. Wong John, Tran Lisa T, Magun Eli A, Magun Bruce E, Wood Lisa J, Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs, Cancer Biology & Therapy, 15, 10, 2014. Crossref

  3. Tsuchiya Kohsuke, Hara Hideki, Fang Rendong, Hernandez-Cuellar Eduardo, Sakai Shunsuke, Daim Sylvia, Chen Xi, Dewamitta Sita R., Qu Huixin, Mitsuyama Masao, Kawamura Ikuo, The adaptor ASC exacerbates lethalListeria monocytogenesinfection by mediating IL-18 production in an inflammasome-dependent and -independent manner, European Journal of Immunology, 44, 12, 2014. Crossref

  4. Uchiyama Ryosuke, Tsutsui Hiroko, Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection, Archivum Immunologiae et Therapiae Experimentalis, 63, 1, 2015. Crossref

  5. Wegiel Barbara, Hauser Carl J., Otterbein Leo E., Heme as a danger molecule in pathogen recognition, Free Radical Biology and Medicine, 89, 2015. Crossref

  6. Esch Kevin J., Schaut Robert G., Lamb Ian M., Clay Gwendolyn, Morais Lima Ádila L., do Nascimento Paulo R.P., Whitley Elizabeth M., Jeronimo Selma M.B., Sutterwala Fayyaz S., Haynes Joseph S., Petersen Christine A., Activation of Autophagy and Nucleotide-Binding Domain Leucine-Rich Repeat–Containing-Like Receptor Family, Pyrin Domain–Containing 3 Inflammasome during Leishmania infantum–Associated Glomerulonephritis, The American Journal of Pathology, 185, 8, 2015. Crossref

  7. Martins João D., Liberal Joana, Silva Ana, Ferreira Isabel, Neves Bruno Miguel, Cruz Maria Teresa, Autophagy and Inflammasome Interplay, DNA and Cell Biology, 34, 4, 2015. Crossref

  8. Hattinger Eva, Wolf Ronald, Caspase-5 rescues UVB-dependent IL-1β activity in ASC-deficient epidermal keratinocytes, Photodermatology, Photoimmunology & Photomedicine, 32, 3, 2016. Crossref

  9. Xiong Xiao-Yi, Liu Liang, Yang Qing-Wu, Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke, Progress in Neurobiology, 142, 2016. Crossref

  10. Zimmermann Arthur, Necrobiology of Liver Cancer: Autophagy and Cellular Senescence, in Tumors and Tumor-Like Lesions of the Hepatobiliary Tract, 2017. Crossref

  11. Ishrat Tauheed, Nasoohi Sanaz, The NLRP3 Inflammasome: A Possible Therapeutic Target for Treatment of Stroke, in Cellular and Molecular Approaches to Regeneration and Repair, 2018. Crossref

  12. Wang Yan, Gao Bo, Xiong Sidong, Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis, American Journal of Physiology-Heart and Circulatory Physiology, 307, 10, 2014. Crossref

  13. Niven Jennifer, Hoare Joseph, McGowan Debbie, Devarajan Gayathri, Itohara Shigeyoshi, Gannagé Monique, Teismann Peter, Crane Isabel, Lewin Alfred S, S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation, PLOS ONE, 10, 7, 2015. Crossref

  14. Uchiyama Ryosuke, Yonehara Shin, Taniguchi Shun’ichiro, Ishido Satoshi, Ishii Ken J., Tsutsui Hiroko, Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo, The Journal of Immunology, 199, 3, 2017. Crossref

  15. Wahlman Carrie, Doyle Timothy M., Little Joshua W., Luongo Livio, Janes Kali, Chen Zhoumou, Esposito Emanuela, Tosh Dilip K., Cuzzocrea Salvatore, Jacobson Kenneth A., Salvemini Daniela, Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms, Pain, 159, 6, 2018. Crossref

  16. Zhang Beibei, Zeng Mengnan, Li Meng, Kan Yuxuan, Li Benke, Xu Ruiqi, Wu Yuanyuan, Wang Shengchao, Zheng Xiaoke, Feng Weisheng, Protopine Protects Mice against LPS-Induced Acute Kidney Injury by Inhibiting Apoptosis and Inflammation via the TLR4 Signaling Pathway, Molecules, 25, 1, 2019. Crossref

  17. Tsuchiya Kohsuke, Nakajima Shinsuke, Hosojima Shoko, Thi Nguyen Dinh, Hattori Tsuyoshi, Manh Le Thuong, Hori Osamu, Mahib Mamunur Rashid, Yamaguchi Yoshifumi, Miura Masayuki, Kinoshita Takeshi, Kushiyama Hiroko, Sakurai Mayumi, Shiroishi Toshihiko, Suda Takashi, Caspase-1 initiates apoptosis in the absence of gasdermin D, Nature Communications, 10, 1, 2019. Crossref

  18. Prearo Moço Natália, Ribeiro de Andrade Ramos Bruna, de Castro Silva Mariana, Polettini Jossimara, Menon Ramkumar, Guimarães da Silva Márcia, Spontaneous Prematurity, Innate Immune System, and Oxidative Stress at the Maternal-Fetal Interface: An Overview, in Translational Studies on Inflammation, 2020. Crossref

  19. Fang Rendong, Uchiyama Ryosuke, Sakai Shunsuke, Hara Hideki, Tsutsui Hiroko, Suda Takashi, Mitsuyama Masao, Kawamura Ikuo, Tsuchiya Kohsuke, ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism, Mucosal Immunology, 12, 5, 2019. Crossref

  20. Doyle Timothy M., Chen Zhoumou, Durante Mariaconcetta, Salvemini Daniela, Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway, The Journal of Pain, 20, 8, 2019. Crossref

  21. Zimmermann Arthur, Necrobiology of Liver Cancer: Autophagy and Cellular Senescence, in Tumors and Tumor-Like Lesions of the Hepatobiliary Tract, 2016. Crossref

  22. Tsuchiya Kohsuke, Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications, Microbiology and Immunology, 64, 4, 2020. Crossref

  23. V. Giridharan Vijayasree, Scaini Giselli, Colpo Gabriela D., Doifode Tejaswini, F. Pinjari Omar, Teixeira Antônio L., Petronilho Fabricia, Macêdo Danielle, Quevedo João, Barichello Tatiana, Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells, Cells, 9, 3, 2020. Crossref

  24. Farr Susan A., Cuzzocrea Salvatore, Esposito Emanuela, Campolo Michela, Niehoff Michael L., Doyle Timothy M., Salvemini Daniela, Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury, Journal of Neuroinflammation, 17, 1, 2020. Crossref

  25. Doyle Timothy M., Largent-Milnes Tally M., Chen Zhoumou, Staikopoulos Vasiliki, Esposito Emanuela, Dalgarno Rebecca, Fan Churmy, Tosh Dilip K., Cuzzocrea Salvatore, Jacobson Kenneth A., Trang Tuan, Hutchinson Mark R., Bennett Gary J., Vanderah Todd W., Salvemini Daniela, Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal, Journal of Pharmacology and Experimental Therapeutics, 374, 2, 2020. Crossref

  26. Xu Dongyi, Wu Xingping, Peng Lianci, Chen Tingting, Huang Qingyuan, Wang Yu, Ye Chao, Peng Yuanyi, Hu Dongliang, Fang Rendong, The Critical Role of NLRP6 Inflammasome in Streptococcus pneumoniae Infection In Vitro and In Vivo, International Journal of Molecular Sciences, 22, 8, 2021. Crossref

  27. Peng Lianci, Jiang Jiali, Chen Tingting, Xu Dongyi, Hou Fengqing, Huang Qingyuan, Peng Yuanyi, Ye Chao, Hu Dong-Liang, Fang Rendong, Toxic Shock Syndrome Toxin 1 Induces Immune Response via the Activation of NLRP3 Inflammasome, Toxins, 13, 1, 2021. Crossref

  28. Zhang Xing-Jie, Shang Kun, Pu Yu-Kun, Wang Qi, Wang Ting-Ting, Zou Yan, Wang Yong-Mei, Xu Yao-Jun, Li Xiao-Li, Zhang Rui-Han, Xiao Wei-Lie, Leojaponin inhibits NLRP3 inflammasome activation through restoration of autophagy via upregulating RAPTOR phosphorylation, Journal of Ethnopharmacology, 278, 2021. Crossref

  29. Lauro Filomena, Giancotti Luigino Antonio, Kolar Grant, Harada Caron Mitsue, Harmon Taylor A., Garrett Timothy J., Salvemini Daniela, Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities, Cellular and Molecular Neurobiology, 2021. Crossref

  30. Tsuchiya Kohsuke, Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity, International Journal of Molecular Sciences, 22, 1, 2021. Crossref

  31. Dai Xue-Yan, Li Xiao-Wei, Zhu Shi-Yong, Li Mu-Zi, Zhao Yi, Talukder Milton, Li Yan-Hua, Li Jin-Long, Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway, Journal of Agricultural and Food Chemistry, 69, 4, 2021. Crossref

  32. Tsuchiya Kohsuke, Hosojima Shoko, Hara Hideki, Kushiyama Hiroko, Mahib Mamunur Rashid, Kinoshita Takeshi, Suda Takashi, Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes, Cell Reports, 34, 12, 2021. Crossref

  33. Fang Rendong, Hara Hideki, Sakai Shunsuke, Hernandez-Cuellar Eduardo, Mitsuyama Masao, Kawamura Ikuo, Tsuchiya Kohsuke, Camilli A., Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection, Infection and Immunity, 82, 6, 2014. Crossref

  34. Lammerding Leoni, Slowik Alexander, Johann Sonja, Beyer Cordian, Zendedel Adib, Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain, Neuroendocrinology, 103, 5, 2016. Crossref

  35. Zou Xin-Sen, Xie Lu, Wang Wen-Yan, Zhao Gao-Yang, Tian Xin-Yue, Chen Meng-Hua, Pomelo peel oil alleviates cerebral NLRP3 inflammasome activation in a cardiopulmonary resuscitation rat model, Experimental and Therapeutic Medicine, 21, 3, 2021. Crossref

  36. Quaresma Juarez Antonio Simões, Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases, Clinical Microbiology Reviews, 32, 4, 2019. Crossref

  37. Chen Huanquan, Zhang Junyan, He Ying, Lv Zhuoyi, Liang Zhengtong, Chen Jianze, Li Peishan, Liu Jiawei, Yang Hongchen, Tao Ailin, Liu Xueting, Exploring the Role of Staphylococcus aureus in Inflammatory Diseases, Toxins, 14, 7, 2022. Crossref

  38. Kaufmann Fernanda N., Costa Ana Paula, Ghisleni Gabriele, Diaz Alexandre P., Rodrigues Ana Lúcia S., Peluffo Hugo, Kaster Manuella P., NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings, Brain, Behavior, and Immunity, 64, 2017. Crossref

  39. Jin Tengchuan, Xiao Tsan Sam, Activation and assembly of the inflammasomes through conserved protein domain families, Apoptosis, 20, 2, 2015. Crossref

  40. de Miguel Diego, Ramirez‐Labrada Ariel, Uranga Iratxe, Hidalgo Sandra, Santiago Llipsy, Galvez Eva María, Arias Maykel, Pardo Julián, Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison, The FEBS Journal, 289, 15, 2022. Crossref

  41. Sagaram Manasa, Royer Amor J., Hu Huirong, Rajhans Abhas, Parthasarathy Ranganathan, Krishnasamy Sathya Sridevi, Mokshagundam Sri Prakash, Kong Maiying, Schwandt Melanie L., Parajuli Dipendra, Cave Matthew C., Vatsalya Vatsalya, Illustration of Gut–Thyroid Axis in Alcohol Use Disorder: Interplay of Gut Dysfunction, Pro-Inflammatory Responses, and Thyroid Function, Cells, 11, 19, 2022. Crossref

近刊の記事

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain