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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2018028252
pages 403-414

Roles of Lamtor1 in Macrophages, CD4+ T-cells, and Regulatory T-cells

Tetsuya Kimura
Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
Atsushi Kumanogoh
Department of Immunopathology, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Clinical Immunology and Respiratory Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Masato Okada
Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan

要約

Lamtor1 is a lysosome-anchored protein that was first reported in 2009. In this review, we describe the discovery and intracellular functions of Lamtor1, as well as physiological roles of Lamtor1 in immune cells, namely, macrophages, CD4+ helper T-cells, and regulatory T-cells. To date, the following three strains of immune cell-specific conditional Lamtor1-knockout mice have been generated: myeloid-specific (LysM-Cre, Lamtor1flox), T-cell-specific (CD4-Cre, Lamtor1flox), and regulatory T-cell-specific (Foxp3-IRES-Cre, Lamtor1flox) knockout mice. The phenotypes observed in Lamtor1-knockouT-cells are partly mediated by decreased mTORC1 activity; however, lipid metabolism, including cholesterol biosynthesis and signaling via 25-hydroxycholesterol, is also involved. Therefore, Lamtor1 dynamically controls cellular function via mTORC1 activation and lipid signaling.


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