ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

巻:
巻 39, 2019 巻 38, 2018 巻 37, 2017 巻 36, 2016 巻 35, 2015 巻 34, 2014 巻 33, 2013 巻 32, 2012 巻 31, 2011 巻 30, 2010 巻 29, 2009 巻 28, 2008 巻 27, 2007 巻 26, 2006 巻 25, 2005 巻 24, 2004 巻 23, 2003 巻 22, 2002 巻 21, 2001 巻 20, 2000 巻 19, 1999 巻 18, 1998 巻 17, 1997 巻 16, 1996 巻 15, 1995 巻 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v30.i2.20
pages 119-130

The Pathogenesis of Murine Coronavirus Infection of the Central Nervous System

Martin P. Hosking
Department of Molecular Biology and Biochemistry, University of California, Irvine, California
Thomas E. Lane
Department of Molecular Biology and Biochemistry, Institute for Immunology, and Sue and Bill Gross Stem Cell Center University of California, Irvine, California

要約

Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute encephalomyelitis that later resolves into a chronic fulminating demyelinating disease. Cytokine production, chemokine secretion, and immune cell infiltration into the central nervous system are critical to control viral replication during acute infection. Despite potent antiviral T-lymphocyte activity, sterile immunity is not achieved, and MHV chronically persists within oligodendrocytes. Continued infiltration and activation of the immune system, a result of the lingering viral antigen and RNA within oligodendrocytes, lead directly to the development of an immune-mediated demyelination that bears remarkable similarities, both clinically and histologically, to the human demyelinating disease multiple sclerosis. MHV offers a unique model system for studying host defense during acute viral infection and immune-mediated demyelination during chronic infection.


Articles with similar content:

The Role of Toll-like Receptors in Regulating the Immune Response against Respiratory Syncytial Virus
Critical Reviews™ in Immunology, Vol.29, 2009, issue 6
Frank Coenjaerts, Grada M. van Bleek, Lydia Tan, Peter Klein Klouwenberg, Wendy Werkman
NK Cells and Their Ability to Modulate T Cells during Virus Infections
Critical Reviews™ in Immunology, Vol.34, 2014, issue 5
Kevin D. Cook, Stephen N. Waggoner, Jason K. Whitmire
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
Critical Reviews™ in Immunology, Vol.33, 2013, issue 4
Alexander J. Gill , Dennis L. Kolson
The Role of Polyunsaturated ω-3 Fatty Acid Eicosapentaenoic Acid−Derived Resolvin E1 (RvE1) in Bone Preservation
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
Robert Gyurko, Thomas E. Van Dyke
Regulation of Immune Responses of the Intestinal Mucosa
Critical Reviews™ in Immunology, Vol.16, 1996, issue 3
Stephan R. Targan, Maria T. Abreu-Martin