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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v14.i3-4.10
pages 193-220

Major Histocompatibility Complex Class I Molecules and Resistance against Intracellular Pathogens

David M. Ojcius
Institut Pasteur, Unite de Biologie Moleculaire du Gene, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France
Christiane Delarbre
Institut Pasteur, Unite de Biologie Moleculaire du Gene, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France
Philippe Kourilsky
Institut Pasteur, Unite de Biologie Moleculaire du Gene, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France
Gabriel Gachelin
Institut Pasteur, Unite de Biologie Moleculaire du Gene, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France

要約

The immune system employs a temporal hierarchy of effector mechanisms to combat infections by intracellular pathogens. The nonspecific response is independent of MHC and can be activated rapidly, while the specific response is slower, more specific, and requires major histocompatibility complex (MHC) molecules. MHC-dependent responses have been characterized extensively in vitro for antigens presented by polymorphic MHC class la and class II proteins and recognized by T lymphocytes carrying α/β T-cell receptors (TcR). Growing indirect evidence has implicated monomorphic MHC class lb proteins and γ/δ T lymphocytes in defense against bacterial infections, but the biochemical and immunological behavior of class lb proteins and γ/δ TcR has not been well characterized, and most hypotheses involving these proteins have relied on data obtained with polymorphic MHC proteins and α/β TcR. An overview of studies describing bacterial infections in vivo suggests that, in many cases, MHC class I-dependent effector cells may not be indispensable for effective immune responses, exerting instead a modulatory effect during the course of infection. Furthermore, many class Ib proteins have probably specialized to present stress antigens and conserved microbial antigens, which may be recognized by γ/δ T cells through an interaction that is qualitatively very different from α/β TcR binding to class I and class II proteins.


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