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Critical Reviews™ in Immunology
インパクトファクター: 1.352 5年インパクトファクター: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v14.i3-4.50
pages 311-336

The Role of Protein Tyrosine Phosphatases in Lymphocyte Activation and Differentiation

Hidetaka Yakura
Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183, Japan

要約

Protein tyrosine phosphorylation is involved in the regulation of every facet of biological phenomena. Signal transduction mechanisms operative in lymphocyte development, activation, and differentiation have been studied intensively, and are also found to support this premise. In this review, I focus on the crucial problems surrounding CD45, a prototypic receptor-type protein tyrosine phosphatase (RPTP) of the immune system: (1) the role of CD45 for antigen receptor-initiated signaling in T and B cells, (2) the physiological relevance of CD45 isoforms, (3) potential regulatory mechanisms of CD45 PTP activity, and (4) the clinical significance of structural abnormalities in PTP. Furthermore, other PTPs that may be important to the exquisite functioning of the immune system are reviewed.


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